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ZIKV rsNS1 in complex with Fab EB9 and anti-fab nanobody

Electron Microscopy
2.8Å resolution
PDB entry 8wo4 coloured by chain, front view.
PDB entry 8wo4 coloured by chain, side view.
PDB entry 8wo4 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine protease NS3 and IG-light kappa chain and IG-heavy chain and IG-heavy chain
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Multimeric state: hetero octamer
Accessible surface area: 82550.86 Å2
Buried surface area: 18308.42 Å2
Dissociation area: 3,431.19 Å2
Dissociation energy (ΔGdiss): -28.2 kcal/mol
Dissociation entropy (TΔSdiss): 54.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-278792

Macromolecules

VL
Chains: A, C
Length: 215 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
VL in PDB entry 8wo4, assembly 1, front view.
VL in PDB entry 8wo4, assembly 1, side view.
VL in PDB entry 8wo4, assembly 1, top view.
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VH
Chains: B, D
Length: 228 amino acids
Theoretical weight: 24.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
VH in PDB entry 8wo4, assembly 1, front view.
VH in PDB entry 8wo4, assembly 1, side view.
VH in PDB entry 8wo4, assembly 1, top view.
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Non-structural protein 1
Chains: E, F
Length: 361 amino acids
Theoretical weight: 41.25 KDa
Source organism: Zika virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q32ZE1 (Residues: 791-1143; Coverage: 10%)
Pfam: Flavivirus non-structural Protein NS1
Non-structural protein 1 in PDB entry 8wo4, assembly 1, front view.
Non-structural protein 1 in PDB entry 8wo4, assembly 1, side view.
Non-structural protein 1 in PDB entry 8wo4, assembly 1, top view.
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Anti-fab nanobody
Chains: G, H
Length: 136 amino acids
Theoretical weight: 15.07 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Anti-fab nanobody in PDB entry 8wo4, assembly 1, front view.
Anti-fab nanobody in PDB entry 8wo4, assembly 1, side view.
Anti-fab nanobody in PDB entry 8wo4, assembly 1, top view.
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