› 8woy

Electron Microscopy
3.14Å resolution

Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 RBD in complex with rabbit ACE2 (local refinement)

Released:
DOI: 10.2210/pdb8woy/pdb
PDB entry 8woy coloured by chain, front view.
PDB entry 8woy coloured by chain, side view.
PDB entry 8woy coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency.
Shi K, Li L, Luo C, Xu Z, Huang B, Ma S, Liu K, Yu G, Gao GF
OpenAccess logo mBio e0298823 (2023)
PMID: 38112468
Related structures: EMD-37702

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236464 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Angiotensin-converting enzyme Chain: A
Molecule details ›
Chain: A
Length: 596 amino acids
Theoretical weight: 69.02 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: G1TEF4 (Residues: 19-614; Coverage: 76%)
Gene name: ACE2
Sequence domains: Angiotensin-converting enzyme
Spike protein S1 Chain: B
Molecule details ›
Chain: B
Length: 229 amino acids
Theoretical weight: 26.08 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 319-539; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.14Å
Relevant EMDB volumes: EMD-37702
Expression systems:
  • Escherichia coli
  • Homo sapiens

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