8wry

Electron Microscopy
2.6Å resolution

Cryo-EM Structure of Mouse TLR4/MD-2/DLAM3 Complex

Released:
Source organism: Mus musculus
Entry authors: Fu Y, Kim H, Kim HM
Related structures: EMD-37794

Function and Biology Details

Reaction catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-575361 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Lymphocyte antigen 96 Chains: C, D
Molecule details ›
Chains: C, D
Length: 142 amino acids
Theoretical weight: 16.41 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9JHF9 (Residues: 19-160; Coverage: 100%)
Gene names: Esop1, Ly96, Md2
Toll-like receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 604 amino acids
Theoretical weight: 68.65 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9QUK6 (Residues: 26-629; Coverage: 75%)
Gene names: Lps, Tlr4
Sequence domains: Leucine rich repeat

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-37794
Expression system: Trichoplusia ni