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Cryo-EM Structure of Mouse TLR4/MD-2/DLAM3 Complex

Electron Microscopy
2.6Å resolution
PDB entry 8wry coloured by chain, front view.
PDB entry 8wry coloured by chain, side view.
PDB entry 8wry coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Toll-like receptor 4 and Lymphocyte antigen 96
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Multimeric state: hetero tetramer
Accessible surface area: 66550.71 Å2
Buried surface area: 15641.45 Å2
Dissociation area: 3,703.9 Å2
Dissociation energy (ΔGdiss): 9.16 kcal/mol
Dissociation entropy (TΔSdiss): 42.01 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-191590

Macromolecules

Lymphocyte antigen 96
Chains: C, D
Length: 142 amino acids
Theoretical weight: 16.41 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9JHF9 (Residues: 19-160; Coverage: 100%)
Gene names: Esop1, Ly96, Md2
Lymphocyte antigen 96 in PDB entry 8wry, assembly 1, front view.
Lymphocyte antigen 96 in PDB entry 8wry, assembly 1, side view.
Lymphocyte antigen 96 in PDB entry 8wry, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9JHF9  
1142102030405060708090100110120130140
 
50100EKQQWFCNSSDAIISYSYCDHLKFPISISSEPCIRLRGTNGFVHVEFIPRGNLKYLYFNLFISVNSIELPKRKEVLCHGHDDDYSFCRALKGETVNTSIPFSFEGILFPKGHYRCVAEAIAGDTEEKLFCLNFTIIHRRDVN
UniProt
Q9JHF9
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
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Toll-like receptor 4
Chains: A, B
Length: 604 amino acids
Theoretical weight: 68.65 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9QUK6 (Residues: 26-629; Coverage: 75%)
Gene names: Lps, Tlr4
Pfam: Leucine rich repeat
Toll-like receptor 4 in PDB entry 8wry, assembly 1, front view.
Toll-like receptor 4 in PDB entry 8wry, assembly 1, side view.
Toll-like receptor 4 in PDB entry 8wry, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9QUK6  
160450100150200250300350400450500550600
 
200400600NPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYK
UniProt
Q9QUK6
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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