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Cryo-EM structure of Staphylococcus aureus sigA-dependent RNAP-promoter open complex

Source organism: Staphylococcus aureus
Biochemical function: DNA binding
Biological process: DNA-templated transcription
Cellular component: DNA-directed RNA polymerase complex

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EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF04561
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase subunit beta
The deposited structure of PDB entry 8x6f contains 2 copies of Pfam domain PF04561 (RNA polymerase Rpb2, domain 2) in DNA-directed RNA polymerase subunit beta. Showing 2 copies in chain C.

PF03118
Domain description: Bacterial RNA polymerase, alpha chain C terminal domain
Occurring in:
  1. DNA-directed RNA polymerase subunit alpha
The deposited structure of PDB entry 8x6f contains 2 copies of Pfam domain PF03118 (Bacterial RNA polymerase, alpha chain C terminal domain) in DNA-directed RNA polymerase subunit alpha. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF01000
Domain description: RNA polymerase Rpb3/RpoA insert domain
Occurring in:
  1. DNA-directed RNA polymerase subunit alpha
The deposited structure of PDB entry 8x6f contains 2 copies of Pfam domain PF01000 (RNA polymerase Rpb3/RpoA insert domain) in DNA-directed RNA polymerase subunit alpha. Showing 1 copy in chain A.

PF01193
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase subunit alpha
The deposited structure of PDB entry 8x6f contains 2 copies of Pfam domain PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerase subunit alpha. Showing 1 copy in chain A.

PF07288
Domain description: RNA polymerase epsilon subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit epsilon
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF07288 (RNA polymerase epsilon subunit) in DNA-directed RNA polymerase subunit epsilon. Showing 1 copy in chain F [auth G].

PF01192
Domain description: RNA polymerase Rpb6
Occurring in:
  1. DNA-directed RNA polymerase subunit omega
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF01192 (RNA polymerase Rpb6 ) in DNA-directed RNA polymerase subunit omega. Showing 1 copy in chain E [auth F].

PF04545
Domain description: Sigma-70, region 4
Occurring in:
  1. RNA polymerase sigma factor SigA
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04545 (Sigma-70, region 4) in RNA polymerase sigma factor SigA. Showing 1 copy in chain G [auth E].

PF04539
Domain description: Sigma-70 region 3
Occurring in:
  1. RNA polymerase sigma factor SigA
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04539 (Sigma-70 region 3) in RNA polymerase sigma factor SigA. Showing 1 copy in chain G [auth E].

PF04542
Domain description: Sigma-70 region 2
Occurring in:
  1. RNA polymerase sigma factor SigA
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04542 (Sigma-70 region 2 ) in RNA polymerase sigma factor SigA. Showing 1 copy in chain G [auth E].

PF00140
Domain description: Sigma-70 factor, region 1.2
Occurring in:
  1. RNA polymerase sigma factor SigA
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF00140 (Sigma-70 factor, region 1.2) in RNA polymerase sigma factor SigA. Showing 1 copy in chain G [auth E].

PF03979
Domain description: Sigma-70 factor, region 1.1
Occurring in:
  1. RNA polymerase sigma factor SigA
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF03979 (Sigma-70 factor, region 1.1) in RNA polymerase sigma factor SigA. Showing 1 copy in chain G [auth E] (this domain is out of the observed residue ranges!).

PF04998
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase subunit beta'
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04998 (RNA polymerase Rpb1, domain 5) in DNA-directed RNA polymerase subunit beta'. Showing 1 copy in chain D.

PF05000
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase subunit beta'
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF05000 (RNA polymerase Rpb1, domain 4) in DNA-directed RNA polymerase subunit beta'. Showing 1 copy in chain D.

PF04983
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase subunit beta'
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04983 (RNA polymerase Rpb1, domain 3) in DNA-directed RNA polymerase subunit beta'. Showing 1 copy in chain D.

PF00623
Domain description: RNA polymerase Rpb1, domain 2
Occurring in:
  1. DNA-directed RNA polymerase subunit beta'
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF00623 (RNA polymerase Rpb1, domain 2) in DNA-directed RNA polymerase subunit beta'. Showing 1 copy in chain D.

PF04997
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase subunit beta'
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04997 (RNA polymerase Rpb1, domain 1) in DNA-directed RNA polymerase subunit beta'. Showing 1 copy in chain D.

PF04560
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase subunit beta
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04560 (RNA polymerase Rpb2, domain 7) in DNA-directed RNA polymerase subunit beta. Showing 1 copy in chain C.

PF00562
Domain description: RNA polymerase Rpb2, domain 6
Occurring in:
  1. DNA-directed RNA polymerase subunit beta
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF00562 (RNA polymerase Rpb2, domain 6) in DNA-directed RNA polymerase subunit beta. Showing 1 copy in chain C.

PF10385
Domain description: RNA polymerase beta subunit external 1 domain
Occurring in:
  1. DNA-directed RNA polymerase subunit beta
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF10385 (RNA polymerase beta subunit external 1 domain) in DNA-directed RNA polymerase subunit beta. Showing 1 copy in chain C.

PF04565
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase subunit beta
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04565 (RNA polymerase Rpb2, domain 3) in DNA-directed RNA polymerase subunit beta. Showing 1 copy in chain C.

PF04563
Domain description: RNA polymerase beta subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit beta
The deposited structure of PDB entry 8x6f contains 1 copy of Pfam domain PF04563 (RNA polymerase beta subunit) in DNA-directed RNA polymerase subunit beta. Showing 1 copy in chain C.

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