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P/Q type calcium channel in complex with omega-Agatoxin IVA

Electron Microscopy
2.92Å resolution
PDB entry 8x93 coloured by chain, front view.
PDB entry 8x93 coloured by chain, side view.
PDB entry 8x93 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Voltage-dependent calcium channel
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Multimeric state: hetero trimer
Accessible surface area: 130666.97 Å2
Buried surface area: 12826.75 Å2
Dissociation area: 2,422.25 Å2
Dissociation energy (ΔGdiss): 10.83 kcal/mol
Dissociation entropy (TΔSdiss): 31.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-241858

Macromolecules

Voltage-dependent L-type calcium channel subunit beta-3
Chain: C
Length: 496 amino acids
Theoretical weight: 56.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54284 (Residues: 1-484; Coverage: 100%)
Gene names: CACNB3, CACNLB3
Pfam:
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8x93, assembly 1, front view.
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8x93, assembly 1, side view.
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8x93, assembly 1, top view.
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Voltage-dependent calcium channel subunit alpha-2/delta-1
Chain: B
Length: 1115 amino acids
Theoretical weight: 126.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 1-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Pfam:
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8x93, assembly 1, front view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8x93, assembly 1, side view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8x93, assembly 1, top view.
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Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Chain: A
Length: 2549 amino acids
Theoretical weight: 287.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O00555 (Residues: 1-2506; Coverage: 100%)
Gene names: CACH4, CACN3, CACNA1A, CACNL1A4
Pfam:
Voltage-dependent P/Q-type calcium channel subunit alpha-1A in PDB entry 8x93, assembly 1, front view.
Voltage-dependent P/Q-type calcium channel subunit alpha-1A in PDB entry 8x93, assembly 1, side view.
Voltage-dependent P/Q-type calcium channel subunit alpha-1A in PDB entry 8x93, assembly 1, top view.
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