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Cryo-EM structure of apo-GPR30-Gq complex structure

Electron Microscopy
2.9Å resolution
PDB entry 8xog coloured by chain, front view.
PDB entry 8xog coloured by chain, side view.
PDB entry 8xog coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 49433.3 Å2
Buried surface area: 11077.33 Å2
Dissociation area: 702.16 Å2
Dissociation energy (ΔGdiss): -4.18 kcal/mol
Dissociation entropy (TΔSdiss): 13.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-246382

Macromolecules

Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 361 amino acids
Theoretical weight: 41.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-19, 32-32, 61-181, 229-229, 251-253, 309-309, 319-319, 347-348; Coverage: 42%)
  • Canonical: P63092 (Residues: 27-38, 40-67, 205-251, 263-273, 277-346, 348-357, 359-386, 389-394; Coverage: 54%)
    • nullnull
Gene names: GNAI1, GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8xog, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8xog, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8xog, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 351 amino acids
Theoretical weight: 38.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8xog, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8xog, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8xog, assembly 1, top view.
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scFv16
Chain: E
Length: 247 amino acids
Theoretical weight: 26.29 KDa
Source organism: synthetic construct
Expression system: Spodoptera frugiperda
scFv16 in PDB entry 8xog, assembly 1, front view.
scFv16 in PDB entry 8xog, assembly 1, side view.
scFv16 in PDB entry 8xog, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8xog, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8xog, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8xog, assembly 1, top view.
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G-protein coupled estrogen receptor 1
Chain: R
Length: 375 amino acids
Theoretical weight: 42.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q99527 (Residues: 1-375; Coverage: 100%)
Gene names: CEPR, CMKRL2, DRY12, GPER, GPER1, GPR30
Pfam: 7 transmembrane receptor (rhodopsin family)
G-protein coupled estrogen receptor 1 in PDB entry 8xog, assembly 1, front view.
G-protein coupled estrogen receptor 1 in PDB entry 8xog, assembly 1, side view.
G-protein coupled estrogen receptor 1 in PDB entry 8xog, assembly 1, top view.
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