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Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline

Electron Microscopy
2Å resolution
PDB entry 8yoo coloured by chain, front view.
PDB entry 8yoo coloured by chain, side view.
PDB entry 8yoo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 81-mer (preferred)
Entry contents: 77 distinct polypeptide molecules
4 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 81-mer
PDBe Complex ID: PDB-CPX-272333

Macromolecules

Large ribosomal subunit protein uL2
Chain: LA
Length: 257 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62917 (Residues: 1-257; Coverage: 100%)
Gene name: RPL8
Pfam:
Large ribosomal subunit protein uL2 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL2 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL2 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL3
Chain: LB
Length: 403 amino acids
Theoretical weight: 46.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P39023 (Residues: 1-403; Coverage: 100%)
Gene names: OK/SW-cl.32, RPL3
Pfam: Ribosomal protein L3
Large ribosomal subunit protein uL3 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL3 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL3 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL4
Chain: LC
Length: 427 amino acids
Theoretical weight: 47.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P36578 (Residues: 1-427; Coverage: 100%)
Gene names: RPL1, RPL4
Pfam:
Large ribosomal subunit protein uL4 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL4 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL4 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL18
Chain: LD
Length: 297 amino acids
Theoretical weight: 34.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46777 (Residues: 1-297; Coverage: 100%)
Gene names: MSTP030, RPL5
Pfam:
Large ribosomal subunit protein uL18 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL18 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL18 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL6
Chain: LE
Length: 288 amino acids
Theoretical weight: 32.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02878 (Residues: 1-288; Coverage: 100%)
Gene names: RPL6, TXREB1
Pfam:
Large ribosomal subunit protein eL6 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL6 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL6 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL30
Chain: LF
Length: 248 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18124 (Residues: 1-248; Coverage: 100%)
Gene name: RPL7
Pfam:
Large ribosomal subunit protein uL30 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL30 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL30 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL8
Chain: LG
Length: 266 amino acids
Theoretical weight: 30.06 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62424 (Residues: 1-266; Coverage: 100%)
Gene names: RPL7A, SURF-3, SURF3
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL8 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL8 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL8 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL6
Chain: LH
Length: 192 amino acids
Theoretical weight: 21.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P32969 (Residues: 1-192; Coverage: 100%)
Gene names: OK/SW-cl.103, RPL9, RPL9P7, RPL9P8, RPL9P9
Pfam: Ribosomal protein L6
Large ribosomal subunit protein uL6 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL6 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL6 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL16
Chain: LI
Length: 214 amino acids
Theoretical weight: 24.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P27635 (Residues: 1-214; Coverage: 100%)
Gene names: DXS648E, QM, RPL10
Pfam: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL16 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL16 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL16 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL5
Chain: LJ
Length: 178 amino acids
Theoretical weight: 20.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62913 (Residues: 1-178; Coverage: 100%)
Gene name: RPL11
Pfam:
Large ribosomal subunit protein uL5 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL5 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL5 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL13
Chain: LL
Length: 211 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P26373 (Residues: 1-211; Coverage: 100%)
Gene names: BBC1, OK/SW-cl.46, RPL13
Pfam: Ribosomal protein L13e
Large ribosomal subunit protein eL13 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL13 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL13 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL14
Chain: LM
Length: 215 amino acids
Theoretical weight: 23.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P50914 (Residues: 1-215; Coverage: 100%)
Gene name: RPL14
Pfam: Ribosomal protein L14
Large ribosomal subunit protein eL14 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL14 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL14 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL15
Chain: LN
Length: 204 amino acids
Theoretical weight: 24.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61313 (Residues: 1-204; Coverage: 100%)
Gene names: EC45, RPL15, TCBAP0781
Pfam: Ribosomal L15
Large ribosomal subunit protein eL15 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL15 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL15 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL13
Chain: LO
Length: 203 amino acids
Theoretical weight: 23.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P40429 (Residues: 1-203; Coverage: 100%)
Gene name: RPL13A
Pfam: Ribosomal protein L13
Large ribosomal subunit protein uL13 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL13 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL13 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL22
Chain: LP
Length: 184 amino acids
Theoretical weight: 21.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18621 (Residues: 1-184; Coverage: 100%)
Gene name: RPL17
Pfam: Ribosomal protein L22p/L17e
Large ribosomal subunit protein uL22 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL22 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL22 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL18
Chain: LQ
Length: 188 amino acids
Theoretical weight: 21.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q07020 (Residues: 1-188; Coverage: 100%)
Gene name: RPL18
Pfam: Ribosomal protein 60S L18 and 50S L18e
Large ribosomal subunit protein eL18 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL18 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL18 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL19
Chain: LR
Length: 196 amino acids
Theoretical weight: 23.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P84098 (Residues: 1-196; Coverage: 100%)
Gene name: RPL19
Pfam: Ribosomal protein L19e
Large ribosomal subunit protein eL19 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL19 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL19 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL20
Chain: LS
Length: 176 amino acids
Theoretical weight: 20.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02543 (Residues: 1-176; Coverage: 100%)
Gene name: RPL18A
Pfam: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Large ribosomal subunit protein eL20 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL20 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL20 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL21
Chain: LT
Length: 160 amino acids
Theoretical weight: 18.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46778 (Residues: 1-160; Coverage: 100%)
Gene name: RPL21
Pfam: Ribosomal protein L21e
Large ribosomal subunit protein eL21 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL21 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL21 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL22
Chain: LU
Length: 128 amino acids
Theoretical weight: 14.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P35268 (Residues: 1-128; Coverage: 100%)
Gene name: RPL22
Pfam: Ribosomal L22e protein family
Large ribosomal subunit protein eL22 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL22 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL22 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL14
Chain: LV
Length: 140 amino acids
Theoretical weight: 14.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62829 (Residues: 1-140; Coverage: 100%)
Gene name: RPL23
Pfam: Ribosomal protein L14p/L23e
Large ribosomal subunit protein uL14 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL14 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL14 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL24
Chain: LW
Length: 157 amino acids
Theoretical weight: 17.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P83731 (Residues: 1-157; Coverage: 100%)
Gene name: RPL24
Pfam: Ribosomal protein L24e
Large ribosomal subunit protein eL24 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL24 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL24 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL23
Chain: LX
Length: 156 amino acids
Theoretical weight: 17.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62750 (Residues: 1-156; Coverage: 100%)
Gene name: RPL23A
Pfam:
Large ribosomal subunit protein uL23 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL23 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL23 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL24
Chain: LY
Length: 145 amino acids
Theoretical weight: 17.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61254 (Residues: 1-145; Coverage: 100%)
Gene name: RPL26
Pfam:
Large ribosomal subunit protein uL24 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL24 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL24 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL27
Chain: LZ
Length: 136 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61353 (Residues: 1-136; Coverage: 100%)
Gene name: RPL27
Pfam:
Large ribosomal subunit protein eL27 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL27 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL27 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL15
Chain: La
Length: 148 amino acids
Theoretical weight: 16.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46776 (Residues: 1-148; Coverage: 100%)
Gene name: RPL27A
Pfam: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein uL15 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL15 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL15 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL29
Chain: Lb
Length: 159 amino acids
Theoretical weight: 17.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P47914 (Residues: 1-159; Coverage: 100%)
Gene name: RPL29
Pfam: Ribosomal L29e protein family
Large ribosomal subunit protein eL29 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL29 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL29 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL30
Chain: Lc
Length: 115 amino acids
Theoretical weight: 12.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62888 (Residues: 1-115; Coverage: 100%)
Gene name: RPL30
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL30 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL30 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL30 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL31
Chain: Ld
Length: 125 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62899 (Residues: 1-125; Coverage: 100%)
Gene name: RPL31
Pfam: Ribosomal protein L31e
Large ribosomal subunit protein eL31 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL31 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL31 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL32
Chain: Le
Length: 135 amino acids
Theoretical weight: 15.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62910 (Residues: 1-135; Coverage: 100%)
Gene names: PP9932, RPL32
Pfam: Ribosomal protein L32
Large ribosomal subunit protein eL32 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL32 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL32 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL33
Chain: Lf
Length: 110 amino acids
Theoretical weight: 12.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18077 (Residues: 1-110; Coverage: 100%)
Gene names: GIG33, RPL35A
Pfam: Ribosomal protein L35Ae
Large ribosomal subunit protein eL33 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL33 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL33 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL34
Chain: Lg
Length: 117 amino acids
Theoretical weight: 13.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49207 (Residues: 1-117; Coverage: 100%)
Gene name: RPL34
Pfam: Ribosomal protein L34e
Large ribosomal subunit protein eL34 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL34 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL34 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL29
Chain: Lh
Length: 123 amino acids
Theoretical weight: 14.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P42766 (Residues: 1-123; Coverage: 100%)
Gene name: RPL35
Pfam: Ribosomal L29 protein
Large ribosomal subunit protein uL29 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL29 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL29 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL36
Chain: Li
Length: 105 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3U8 (Residues: 1-105; Coverage: 100%)
Gene name: RPL36
Pfam: Ribosomal protein L36e
Large ribosomal subunit protein eL36 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL36 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL36 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL37
Chain: Lj
Length: 97 amino acids
Theoretical weight: 11.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61927 (Residues: 1-97; Coverage: 100%)
Gene name: RPL37
Pfam: Ribosomal protein L37e
Large ribosomal subunit protein eL37 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL37 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL37 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL38
Chain: Lk
Length: 70 amino acids
Theoretical weight: 8.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63173 (Residues: 1-70; Coverage: 100%)
Gene name: RPL38
Pfam: Ribosomal L38e protein family
Large ribosomal subunit protein eL38 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL38 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL38 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL39
Chain: Ll
Length: 51 amino acids
Theoretical weight: 6.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62891 (Residues: 1-51; Coverage: 100%)
Gene name: RPL39
Pfam: Ribosomal L39 protein
Large ribosomal subunit protein eL39 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL39 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL39 in PDB entry 8yoo, assembly 1, top view.
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Ubiquitin-ribosomal protein eL40 fusion protein
Chain: Lm
Length: 128 amino acids
Theoretical weight: 14.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62987 (Residues: 1-128; Coverage: 100%)
Gene names: UBA52, UBCEP2
Pfam:
Ubiquitin-ribosomal protein eL40 fusion protein in PDB entry 8yoo, assembly 1, front view.
Ubiquitin-ribosomal protein eL40 fusion protein in PDB entry 8yoo, assembly 1, side view.
Ubiquitin-ribosomal protein eL40 fusion protein in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS32
Chain: Ln
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62945 (Residues: 1-25; Coverage: 100%)
Gene name: RPL41
Pfam: Ribosomal protein L41
Small ribosomal subunit protein eS32 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS32 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS32 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL42
Chain: Lo
Length: 106 amino acids
Theoretical weight: 12.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P83881 (Residues: 1-106; Coverage: 100%)
Gene names: GIG15, MIG6, RPL36A, RPL44
Pfam: Ribosomal protein L44
Large ribosomal subunit protein eL42 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL42 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL42 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL43
Chain: Lp
Length: 92 amino acids
Theoretical weight: 10.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61513 (Residues: 1-92; Coverage: 100%)
Gene name: RPL37A
Pfam: Ribosomal L37ae protein family
Large ribosomal subunit protein eL43 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL43 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL43 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein eL28
Chain: Lr
Length: 137 amino acids
Theoretical weight: 15.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46779 (Residues: 1-137; Coverage: 100%)
Gene name: RPL28
Pfam: Ribosomal L28e protein family
Large ribosomal subunit protein eL28 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein eL28 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein eL28 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL10
Chain: Ls
Length: 317 amino acids
Theoretical weight: 34.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05388 (Residues: 1-317; Coverage: 100%)
Gene name: RPLP0
Pfam:
Large ribosomal subunit protein uL10 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL10 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL10 in PDB entry 8yoo, assembly 1, top view.
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Large ribosomal subunit protein uL11
Chain: Lt
Length: 165 amino acids
Theoretical weight: 17.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P30050 (Residues: 1-165; Coverage: 100%)
Gene name: RPL12
Pfam:
Large ribosomal subunit protein uL11 in PDB entry 8yoo, assembly 1, front view.
Large ribosomal subunit protein uL11 in PDB entry 8yoo, assembly 1, side view.
Large ribosomal subunit protein uL11 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS2
Chain: SA
Length: 295 amino acids
Theoretical weight: 32.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08865 (Residues: 1-295; Coverage: 100%)
Gene names: LAMBR, LAMR1, RPSA
Pfam:
Small ribosomal subunit protein uS2 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS2 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS2 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS1
Chain: SB
Length: 264 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61247 (Residues: 1-264; Coverage: 100%)
Gene names: FTE1, MFTL, RPS3A
Pfam: Ribosomal S3Ae family
Small ribosomal subunit protein eS1 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS1 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS1 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS3
Chain: SD
Length: 243 amino acids
Theoretical weight: 26.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P23396 (Residues: 1-243; Coverage: 100%)
Gene names: OK/SW-cl.26, RPS3
Pfam:
Small ribosomal subunit protein uS3 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS3 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS3 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS4, X isoform
Chain: SE
Length: 263 amino acids
Theoretical weight: 29.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62701 (Residues: 1-263; Coverage: 100%)
Gene names: CCG2, RPS4, RPS4X, SCAR
Pfam:
Small ribosomal subunit protein eS4, X isoform in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS4, X isoform in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS4, X isoform in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS7
Chain: SF
Length: 204 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46782 (Residues: 1-204; Coverage: 100%)
Gene name: RPS5
Pfam: Ribosomal protein S7p/S5e
Small ribosomal subunit protein uS7 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS7 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS7 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS7
Chain: SH
Length: 194 amino acids
Theoretical weight: 22.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62081 (Residues: 1-194; Coverage: 100%)
Gene name: RPS7
Pfam: Ribosomal protein S7e
Small ribosomal subunit protein eS7 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS7 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS7 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS8
Chain: SI
Length: 208 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62241 (Residues: 1-208; Coverage: 100%)
Gene names: OK/SW-cl.83, RPS8
Pfam: Ribosomal protein S8e
Small ribosomal subunit protein eS8 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS8 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS8 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS10
Chain: SK
Length: 165 amino acids
Theoretical weight: 18.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46783 (Residues: 1-165; Coverage: 100%)
Gene name: RPS10
Pfam: Plectin/S10 domain
Small ribosomal subunit protein eS10 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS10 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS10 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS17
Chain: SL
Length: 158 amino acids
Theoretical weight: 18.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62280 (Residues: 1-158; Coverage: 100%)
Gene name: RPS11
Pfam:
Small ribosomal subunit protein uS17 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS17 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS17 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS19
Chain: SP
Length: 145 amino acids
Theoretical weight: 17.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62841 (Residues: 1-145; Coverage: 100%)
Gene names: RIG, RPS15
Pfam: Ribosomal protein S19
Small ribosomal subunit protein uS19 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS19 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS19 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS9
Chain: SQ
Length: 146 amino acids
Theoretical weight: 16.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62249 (Residues: 1-146; Coverage: 100%)
Gene name: RPS16
Pfam: Ribosomal protein S9/S16
Small ribosomal subunit protein uS9 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS9 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS9 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS17
Chain: SR
Length: 135 amino acids
Theoretical weight: 15.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08708 (Residues: 1-135; Coverage: 100%)
Gene names: RPS17, RPS17L
Pfam: Ribosomal S17
Small ribosomal subunit protein eS17 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS17 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS17 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS13
Chain: SS
Length: 152 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62269 (Residues: 1-152; Coverage: 100%)
Gene names: D6S218E, RPS18
Pfam: Ribosomal protein S13/S18
Small ribosomal subunit protein uS13 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS13 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS13 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS19
Chain: ST
Length: 145 amino acids
Theoretical weight: 16.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P39019 (Residues: 1-145; Coverage: 100%)
Gene name: RPS19
Pfam: Ribosomal protein S19e
Small ribosomal subunit protein eS19 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS19 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS19 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS10
Chain: SU
Length: 119 amino acids
Theoretical weight: 13.4 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60866 (Residues: 1-119; Coverage: 100%)
Gene name: RPS20
Pfam: Ribosomal protein S10p/S20e
Small ribosomal subunit protein uS10 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS10 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS10 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS21
Chain: SV
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63220 (Residues: 1-83; Coverage: 100%)
Gene name: RPS21
Pfam: Ribosomal protein S21e
Small ribosomal subunit protein eS21 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS21 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS21 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS12
Chain: SX
Length: 143 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62266 (Residues: 1-143; Coverage: 100%)
Gene name: RPS23
Pfam: Ribosomal protein S12/S23
Small ribosomal subunit protein uS12 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS12 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS12 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS26
Chain: Sa
Length: 115 amino acids
Theoretical weight: 13.05 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62854 (Residues: 1-115; Coverage: 100%)
Gene name: RPS26
Pfam: Ribosomal protein S26e
Small ribosomal subunit protein eS26 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS26 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS26 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS28
Chain: Sc
Length: 69 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62857 (Residues: 1-69; Coverage: 100%)
Gene name: RPS28
Pfam: Ribosomal protein S28e
Small ribosomal subunit protein eS28 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS28 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS28 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS14
Chain: Sd
Length: 56 amino acids
Theoretical weight: 6.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62273 (Residues: 1-56; Coverage: 100%)
Gene name: RPS29
Pfam: Ribosomal protein S14p/S29e
Small ribosomal subunit protein uS14 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS14 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS14 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein RACK1
Chain: Sg
Length: 317 amino acids
Theoretical weight: 35.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63244 (Residues: 1-317; Coverage: 100%)
Gene names: GNB2L1, HLC7, PIG21, RACK1
Pfam: WD domain, G-beta repeat
Small ribosomal subunit protein RACK1 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein RACK1 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein RACK1 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS5
Chain: SC
Length: 293 amino acids
Theoretical weight: 31.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P15880 (Residues: 1-293; Coverage: 100%)
Gene names: RPS2, RPS4
Pfam:
Small ribosomal subunit protein uS5 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS5 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS5 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS6
Chain: SG
Length: 249 amino acids
Theoretical weight: 28.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62753 (Residues: 1-249; Coverage: 100%)
Gene names: OK/SW-cl.2, RPS6
Pfam: Ribosomal protein S6e
Small ribosomal subunit protein eS6 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS6 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS6 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS4
Chain: SJ
Length: 194 amino acids
Theoretical weight: 22.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46781 (Residues: 1-194; Coverage: 100%)
Gene name: RPS9
Pfam:
Small ribosomal subunit protein uS4 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS4 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS4 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS12
Chain: SM
Length: 132 amino acids
Theoretical weight: 14.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25398 (Residues: 1-132; Coverage: 100%)
Gene name: RPS12
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Small ribosomal subunit protein eS12 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS12 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS12 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS15
Chain: SN
Length: 151 amino acids
Theoretical weight: 17.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62277 (Residues: 1-151; Coverage: 100%)
Gene name: RPS13
Pfam:
Small ribosomal subunit protein uS15 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS15 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS15 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS11
Chain: SO
Length: 151 amino acids
Theoretical weight: 16.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62263 (Residues: 1-151; Coverage: 100%)
Gene names: PRO2640, RPS14
Pfam: Ribosomal protein S11
Small ribosomal subunit protein uS11 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS11 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS11 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein uS8
Chain: SW
Length: 130 amino acids
Theoretical weight: 14.87 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62244 (Residues: 1-130; Coverage: 100%)
Gene names: OK/SW-cl.82, RPS15A
Pfam: Ribosomal protein S8
Small ribosomal subunit protein uS8 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein uS8 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein uS8 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS24
Chain: SY
Length: 133 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62847 (Residues: 1-133; Coverage: 100%)
Gene name: RPS24
Pfam: Ribosomal protein S24e
Small ribosomal subunit protein eS24 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS24 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS24 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS25
Chain: SZ
Length: 125 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62851 (Residues: 1-125; Coverage: 100%)
Gene name: RPS25
Pfam: S25 ribosomal protein
Small ribosomal subunit protein eS25 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS25 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS25 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS27
Chain: Sb
Length: 84 amino acids
Theoretical weight: 9.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P42677 (Residues: 1-84; Coverage: 100%)
Gene names: MPS1, RPS27
Pfam: Ribosomal protein S27
Small ribosomal subunit protein eS27 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS27 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS27 in PDB entry 8yoo, assembly 1, top view.
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Small ribosomal subunit protein eS30
Chain: Se
Length: 59 amino acids
Theoretical weight: 6.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62861 (Residues: 75-133; Coverage: 44%)
Gene name: FAU
Pfam: Ribosomal protein S30
Small ribosomal subunit protein eS30 in PDB entry 8yoo, assembly 1, front view.
Small ribosomal subunit protein eS30 in PDB entry 8yoo, assembly 1, side view.
Small ribosomal subunit protein eS30 in PDB entry 8yoo, assembly 1, top view.
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Ubiquitin-ribosomal protein eS31 fusion protein
Chain: Sf
Length: 156 amino acids
Theoretical weight: 18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62979 (Residues: 1-156; Coverage: 100%)
Gene names: RPS27A, UBA80, UBCEP1
Pfam:
Ubiquitin-ribosomal protein eS31 fusion protein in PDB entry 8yoo, assembly 1, front view.
Ubiquitin-ribosomal protein eS31 fusion protein in PDB entry 8yoo, assembly 1, side view.
Ubiquitin-ribosomal protein eS31 fusion protein in PDB entry 8yoo, assembly 1, top view.
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RNA chain L5
Name: 28S ribosomal RNA
Representative chains: L5
Length: 5070 nucleotides
Theoretical weight: 1640.18 KDa
Rfam: Eukaryotic large subunit ribosomal RNA
28S ribosomal RNA in PDB entry 8yoo, assembly 1, front view.
28S ribosomal RNA in PDB entry 8yoo, assembly 1, side view.
28S ribosomal RNA in PDB entry 8yoo, assembly 1, top view.
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RNA chain L7
Name: 5S ribosomal RNA
Representative chains: L7
Length: 121 nucleotides
Theoretical weight: 39 KDa
Rfam: 5S ribosomal RNA
5S ribosomal RNA in PDB entry 8yoo, assembly 1, front view.
5S ribosomal RNA in PDB entry 8yoo, assembly 1, side view.
5S ribosomal RNA in PDB entry 8yoo, assembly 1, top view.
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RNA chain L8
Name: 5.8S ribosomal RNA
Representative chains: L8
Length: 157 nucleotides
Theoretical weight: 50.45 KDa
Rfam: 5.8S ribosomal RNA
5.8S ribosomal RNA in PDB entry 8yoo, assembly 1, front view.
5.8S ribosomal RNA in PDB entry 8yoo, assembly 1, side view.
5.8S ribosomal RNA in PDB entry 8yoo, assembly 1, top view.
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RNA chain S2
Name: 18S Ribosomal RNA
Representative chains: S2
Length: 1869 nucleotides
Theoretical weight: 602.75 KDa
Rfam: Eukaryotic small subunit ribosomal RNA
18S Ribosomal RNA in PDB entry 8yoo, assembly 1, front view.
18S Ribosomal RNA in PDB entry 8yoo, assembly 1, side view.
18S Ribosomal RNA in PDB entry 8yoo, assembly 1, top view.
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