Function and Biology

Human DNA polymerase theta helicase domain in complex with AMP-PNP, dimer form

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: not assigned
Cellular component: not assigned

EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

EC 2.7.7.49: RNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • DNA nucleotidyltransferase (RNA-directed)
  • RNA revertase
  • RNA-dependent DNA polymerase
  • RNA-dependent deoxyribonucleate nucleotidyltransferase
  • RNA-instructed DNA polymerase
  • RT
  • Reverse transcriptase
  • Revertase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF21099
Domain description: DNA_pol_Q helicase like region helical domain
Occurring in:
  1. DNA polymerase theta
The deposited structure of PDB entry 9asj contains 2 copies of Pfam domain PF21099 (DNA_pol_Q helicase like region helical domain) in DNA polymerase theta. Showing 1 copy in chain A.

PF20470
Domain description: Helix-turn-helix domain
Occurring in:
  1. DNA polymerase theta
The deposited structure of PDB entry 9asj contains 2 copies of Pfam domain PF20470 (Helix-turn-helix domain) in DNA polymerase theta. Showing 1 copy in chain A.

PF00271
Domain description: Helicase conserved C-terminal domain
Occurring in:
  1. DNA polymerase theta
The deposited structure of PDB entry 9asj contains 2 copies of Pfam domain PF00271 (Helicase conserved C-terminal domain) in DNA polymerase theta. Showing 1 copy in chain A.

PF00270
Domain description: DEAD/DEAH box helicase
Occurring in:
  1. DNA polymerase theta
The deposited structure of PDB entry 9asj contains 2 copies of Pfam domain PF00270 (DEAD/DEAH box helicase) in DNA polymerase theta. Showing 1 copy in chain A.