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Cryo-EM structure of the human TRPM4 channel in the presence of EDTA at 37 degrees Celsius

Electron Microscopy
3.1Å resolution
PDB entry 9b93 coloured by chain, front view.
PDB entry 9b93 coloured by chain, side view.
PDB entry 9b93 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transient receptor potential cation channel subfamily M member 4
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Multimeric state: homo tetramer
Accessible surface area: 168734.24 Å2
Buried surface area: 26659.41 Å2
Dissociation area: 13,329.71 Å2
Dissociation energy (ΔGdiss): 196.74 kcal/mol
Dissociation entropy (TΔSdiss): 53.92 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-186204

Macromolecules

Transient receptor potential cation channel subfamily M member 4
Chains: A, B, C, D
Length: 1214 amino acids
Theoretical weight: 134.46 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: Q8TD43 (Residues: 1-1214; Coverage: 100%)
Gene names: LTRPC4, TRPM4
Pfam:
Transient receptor potential cation channel subfamily M member 4 in PDB entry 9b93, assembly 1, front view.
Transient receptor potential cation channel subfamily M member 4 in PDB entry 9b93, assembly 1, side view.
Transient receptor potential cation channel subfamily M member 4 in PDB entry 9b93, assembly 1, top view.
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