› 9bc6

Electron Microscopy
2.5Å resolution

HCN1 M305L with propofol

Released:
DOI: 10.2210/pdb9bc6/pdb
PDB entry 9bc6 coloured by chain, front view.
PDB entry 9bc6 coloured by chain, side view.
PDB entry 9bc6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM
Nature (2024)
PMID: 39085604
Related structures: EMD-44425

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130083 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 660 amino acids
Theoretical weight: 74.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60741 (Residues: 1-890; Coverage: 74%)
Gene names: BCNG1, HCN1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PCW 8 x PCW
Ligand PFL 4 x PFL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-44425
Expression system: Homo sapiens

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