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HCN1 M305L with propofol

Electron Microscopy
2.5Å resolution
PDB entry 9bc6 coloured by chain, front view.
PDB entry 9bc6 coloured by chain, side view.
PDB entry 9bc6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: HCN1 channel complex
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Multimeric state: homo tetramer
Accessible surface area: 85742.25 Å2
Buried surface area: 30910.09 Å2
Dissociation area: 12,632.09 Å2
Dissociation energy (ΔGdiss): 145.01 kcal/mol
Dissociation entropy (TΔSdiss): 49.32 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-130083
Complex Portal ID: CPX-261

Macromolecules

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Chains: A, B, C, D
Length: 660 amino acids
Theoretical weight: 74.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60741 (Residues: 1-890; Coverage: 74%)
Gene names: BCNG1, HCN1
Pfam:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 in PDB entry 9bc6, assembly 1, front view.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 in PDB entry 9bc6, assembly 1, side view.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 in PDB entry 9bc6, assembly 1, top view.
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