› 9c81

X-ray diffraction
1.7Å resolution

X-ray crystal structure of AmpC beta-lactamase with inhibitor

Released:
DOI: 10.2210/pdb9c81/pdb
PDB entry 9c81 coloured by chain, front view.
PDB entry 9c81 coloured by chain, side view.
PDB entry 9c81 coloured by chain, top view.
Source organism: Escherichia coli
Entry authors: Liu F, Shoichet BK, Bassim V

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chains: A, B
Molecule details ›
Chains: A, B
Length: 377 amino acids
Theoretical weight: 41.59 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P00811 (Residues: 1-377; Coverage: 100%)
Gene names: JW4111, ampA, ampC, b4150
Sequence domains: Beta-lactamase

Ligands and Environments

1 bound ligand:
Ligand A1AU0 2 x A1AU0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2
Unit cell:
a: 119.03Å b: 78.17Å c: 97.72Å
α: 90° β: 115.48° γ: 90°
R-values:
R R work R free
0.188 0.188 0.214
Expression system: Escherichia coli

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