› › Structure analysis

SARS-CoV-2 nsp10-16 methyltransferase in complex with SAM and m7GTP

X-ray diffraction
2.33Å resolution
PDB entry 9eun coloured by chain, front view.
PDB entry 9eun coloured by chain, side view.
PDB entry 9eun coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: SARS-CoV-2 NSP10-NSP16 2'-O-methyltransferase complex
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 19388.58 Å2
Buried surface area: 5156.64 Å2
Dissociation area: 1,071.9 Å2
Dissociation energy (ΔGdiss): -0.61 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145023
Complex Portal ID: CPX-5688

Macromolecules

2'-O-methyltransferase nsp16
Chain: A
Length: 304 amino acids
Theoretical weight: 34.15 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DTD1 (Residues: 6799-7096; Coverage: 4%)
Gene names: 1a-1b, rep
Pfam: Coronavirus 2'-O-methyltransferase
2'-O-methyltransferase nsp16 in PDB entry 9eun, assembly 1, front view.
2'-O-methyltransferase nsp16 in PDB entry 9eun, assembly 1, side view.
2'-O-methyltransferase nsp16 in PDB entry 9eun, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P0DTD1  
130420406080100120140160180200220240260280300
 
100200300
UniProt
P0DTD1
Chains
Ligand binding sites
Interaction interfaces
Molecule details ›

Search similar proteins

Non-structural protein 10
Chain: B
Length: 140 amino acids
Theoretical weight: 14.86 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DTD1 (Residues: 4254-4392; Coverage: 2%)
Gene names: 1a-1b, rep
Pfam: Coronavirus RNA synthesis protein NSP10
Non-structural protein 10 in PDB entry 9eun, assembly 1, front view.
Non-structural protein 10 in PDB entry 9eun, assembly 1, side view.
Non-structural protein 10 in PDB entry 9eun, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P0DTD1  
Loading Protvista...
Molecule details ›

Search similar proteins

Quick links