› 9euu

Electron Microscopy
1.93Å resolution

Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo

Released:
DOI: 10.2210/pdb9euu/pdb
PDB entry 9euu coloured by chain, front view.
PDB entry 9euu coloured by chain, side view.
PDB entry 9euu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Burger D, Kashyrina M, Lewis A, De Nuccio F, Mohammed I, de La Seigliere H, van den Heuvel L, Feuillie C, Verchere J, Berbon M, Arotcarena M, Retailleau A, Bezard E, Laferriere F, Loquet A, Bousset L, Baron T, Lofrumento DD, De Giorgi F, Stahlberg H, Ichas F
Related structures: EMD-19986

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273664 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 1.93Å
Relevant EMDB volumes: EMD-19986
Expression system: Escherichia coli BL21

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