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Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo

Electron Microscopy
1.93Å resolution
PDB entry 9euu coloured by chain, front view.
PDB entry 9euu coloured by chain, side view.
PDB entry 9euu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo octadecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-synuclein
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Multimeric state: homo octadecamer
Accessible surface area: 32755.01 Å2
Buried surface area: 80300.36 Å2
Dissociation area: 3,329.31 Å2
Dissociation energy (ΔGdiss): 17.36 kcal/mol
Dissociation entropy (TΔSdiss): 14.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-273664

Macromolecules

Alpha-synuclein
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Pfam: Synuclein
Alpha-synuclein in PDB entry 9euu, assembly 1, front view.
Alpha-synuclein in PDB entry 9euu, assembly 1, side view.
Alpha-synuclein in PDB entry 9euu, assembly 1, top view.
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