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Vitamin D receptor complex with 1,4b,25-trihydroxyvitamin D3

X-ray diffraction
1.8Å resolution
PDB entry 9ez2 coloured by chain, front view.
PDB entry 9ez2 coloured by chain, side view.
PDB entry 9ez2 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Vitamin D3 receptor A and Nuclear receptor coactivator 2
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Multimeric state: hetero tetramer
Accessible surface area: 22211.65 Å2
Buried surface area: 4655.4 Å2
Dissociation area: 900.76 Å2
Dissociation energy (ΔGdiss): 5.86 kcal/mol
Dissociation entropy (TΔSdiss): 13.05 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172336

Macromolecules

Vitamin D3 receptor A
Chain: A
Length: 302 amino acids
Theoretical weight: 34.06 KDa
Source organism: Danio rerio
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9PTN2 (Residues: 156-453; Coverage: 66%)
Gene names: nr1i1a, vdr, vdra
Pfam: Ligand-binding domain of nuclear hormone receptor
Vitamin D3 receptor A in PDB entry 9ez2, assembly 1, front view.
Vitamin D3 receptor A in PDB entry 9ez2, assembly 1, side view.
Vitamin D3 receptor A in PDB entry 9ez2, assembly 1, top view.
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Nuclear receptor coactivator 2
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2
Nuclear receptor coactivator 2 in PDB entry 9ez2, assembly 1, front view.
Nuclear receptor coactivator 2 in PDB entry 9ez2, assembly 1, side view.
Nuclear receptor coactivator 2 in PDB entry 9ez2, assembly 1, top view.
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