› 9f43

Electron Microscopy
3.49Å resolution

cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR

Released:
DOI: 10.2210/pdb9f43/pdb
PDB entry 9f43 coloured by chain, front view.
PDB entry 9f43 coloured by chain, side view.
PDB entry 9f43 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Battaglioni S, Craigie LM, Filippini S, Maier T, Hall MN
Proc Natl Acad Sci U S A 121 e2405959121 (2024)
PMID: 39141345
Related structures: EMD-50182

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275154 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Regulatory-associated protein of mTOR Chain: E
Molecule details ›
Chain: E
Length: 1363 amino acids
Theoretical weight: 152.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8N122 (Residues: 1-1335; Coverage: 100%)
Gene names: KIAA1303, RAPTOR, RPTOR
Sequence domains:
Lateral signaling target protein 2 homolog Chain: G
Molecule details ›
Chain: G
Length: 887 amino acids
Theoretical weight: 96.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9HCC9 (Residues: 1-887; Coverage: 100%)
Gene names: KIAA1643, LST2, ZFYVE28
Sequence domains: FYVE zinc finger

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.49Å
Relevant EMDB volumes: EMD-50182
Expression system: Spodoptera frugiperda

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