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cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR

Electron Microscopy
3.49Å resolution
PDB entry 9f43 coloured by chain, front view.
PDB entry 9f43 coloured by chain, side view.
PDB entry 9f43 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Regulatory-associated protein of mTOR and Lateral signaling target protein 2 homolog
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Multimeric state: hetero dimer
Accessible surface area: 45342.98 Å2
Buried surface area: 1575.96 Å2
Dissociation area: 787.98 Å2
Dissociation energy (ΔGdiss): 1.93 kcal/mol
Dissociation entropy (TΔSdiss): 7.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-275154

Macromolecules

Regulatory-associated protein of mTOR
Chain: E
Length: 1363 amino acids
Theoretical weight: 152.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8N122 (Residues: 1-1335; Coverage: 100%)
Gene names: KIAA1303, RAPTOR, RPTOR
Pfam:
Regulatory-associated protein of mTOR in PDB entry 9f43, assembly 1, front view.
Regulatory-associated protein of mTOR in PDB entry 9f43, assembly 1, side view.
Regulatory-associated protein of mTOR in PDB entry 9f43, assembly 1, top view.
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Lateral signaling target protein 2 homolog
Chain: G
Length: 887 amino acids
Theoretical weight: 96.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9HCC9 (Residues: 1-887; Coverage: 100%)
Gene names: KIAA1643, LST2, ZFYVE28
Pfam: FYVE zinc finger
Lateral signaling target protein 2 homolog in PDB entry 9f43, assembly 1, front view.
Lateral signaling target protein 2 homolog in PDB entry 9f43, assembly 1, side view.
Lateral signaling target protein 2 homolog in PDB entry 9f43, assembly 1, top view.
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