› 9gzp

Electron Microscopy
2.9Å resolution

WT-IAPP cryo-EM structure Type LL - control reaction

Released:
DOI: 10.2210/pdb9gzp/pdb
PDB entry 9gzp coloured by chain, front view.
PDB entry 9gzp coloured by chain, side view.
PDB entry 9gzp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
Taylor AIP, Xu Y, Wilkinson M, Chakraborty P, Brinkworth A, Willis LF, Zhuravleva A, Ranson NA, Foster R, Radford SE
J Am Chem Soc (2025)
PMID: 39985130
Related structures: EMD-51730

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145617 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 38 amino acids
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Gene name: IAPP
Sequence domains: Calcitonin / CGRP / IAPP family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.9Å
Relevant EMDB volumes: EMD-51730
Expression system: Not provided

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