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WT-IAPP cryo-EM structure Type LL - control reaction

Electron Microscopy
2.9Å resolution
PDB entry 9gzp coloured by chain, front view.
PDB entry 9gzp coloured by chain, side view.
PDB entry 9gzp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dodecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Islet amyloid polypeptide
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Multimeric state: homo dodecamer
Accessible surface area: 12276.95 Å2
Buried surface area: 24614.8 Å2
Dissociation area: 3,221.77 Å2
Dissociation energy (ΔGdiss): 42.04 kcal/mol
Dissociation entropy (TΔSdiss): 12.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145617

Macromolecules

Islet amyloid polypeptide
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 38 amino acids
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Gene name: IAPP
Pfam: Calcitonin / CGRP / IAPP family
Islet amyloid polypeptide in PDB entry 9gzp, assembly 1, front view.
Islet amyloid polypeptide in PDB entry 9gzp, assembly 1, side view.
Islet amyloid polypeptide in PDB entry 9gzp, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P10997  
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