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Crystal structure of IL-17A in complex with compound 18

X-ray diffraction
2.117Å resolution
PDB entry 9h4d coloured by chain, front view.
PDB entry 9h4d coloured by chain, side view.
PDB entry 9h4d coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interleukin-17A complex
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Multimeric state: homo dimer
Accessible surface area: 11195.0 Å2
Buried surface area: 4783.73 Å2
Dissociation area: 2,391.86 Å2
Dissociation energy (ΔGdiss): 27.9 kcal/mol
Dissociation entropy (TΔSdiss): 12.19 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172495

Macromolecules

Interleukin-17A
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16552 (Residues: 34-155; Coverage: 92%)
Gene names: CTLA8, IL17, IL17A
Pfam: Interleukin-17
Interleukin-17A in PDB entry 9h4d, assembly 1, front view.
Interleukin-17A in PDB entry 9h4d, assembly 1, side view.
Interleukin-17A in PDB entry 9h4d, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q16552  
1123102030405060708090100110120
 
50100
UniProt
Q16552
Chains
Ligand binding sites
Interaction interfaces
Sequence conservation
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