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Human MTHFD1 in complex with compound 16e

X-ray diffraction
2.06Å resolution
PDB entry 9isl coloured by chain, front view.
PDB entry 9isl coloured by chain, side view.
PDB entry 9isl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed
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Multimeric state: homo tetramer
Accessible surface area: 44172.32 Å2
Buried surface area: 11029.94 Å2
Dissociation area: 592.93 Å2
Dissociation energy (ΔGdiss): -11.4 kcal/mol
Dissociation entropy (TΔSdiss): 13.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-283481

Macromolecules

C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed
Chains: A, B, C, D
Length: 309 amino acids
Theoretical weight: 33.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11586 (Residues: 1-301; Coverage: 32%)
Gene names: MTHFC, MTHFD, MTHFD1
Pfam:
C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed in PDB entry 9isl, assembly 1, front view.
C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed in PDB entry 9isl, assembly 1, side view.
C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed in PDB entry 9isl, assembly 1, top view.
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