9ivg

Electron Microscopy
3Å resolution

Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex

Released:
Source organism: Homo sapiens
Related structures: EMD-60927

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-283458 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Glucagon-like peptide 1(7-36) Chain: P
Molecule details ›
Chain: P
Length: 28 amino acids
Theoretical weight: 3.09 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01275 (Residues: 100-127; Coverage: 18%)
Gene name: GCG
Sequence domains: Peptide hormone
Glucagon-like peptide 1 receptor Chain: R
Molecule details ›
Chain: R
Length: 440 amino acids
Theoretical weight: 50.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P43220 (Residues: 24-463; Coverage: 100%)
Gene name: GLP1R
Sequence domains:
Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Nanobody-35 Chain: N

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-60927
Expression system: Trichoplusia ni