› › Structure analysis

Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex

Electron Microscopy
3Å resolution
PDB entry 9ivg coloured by chain, front view.
PDB entry 9ivg coloured by chain, side view.
PDB entry 9ivg coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero hexamer
Accessible surface area: 54158.58 Å2
Buried surface area: 14577.09 Å2
Dissociation area: 2,568.41 Å2
Dissociation energy (ΔGdiss): -5.38 kcal/mol
Dissociation entropy (TΔSdiss): 27.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-283458

Macromolecules

Glucagon-like peptide 1(7-36)
Chain: P
Length: 28 amino acids
Theoretical weight: 3.09 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01275 (Residues: 100-127; Coverage: 18%)
Gene name: GCG
Pfam: Peptide hormone
GLP-1(9-36) in PDB entry 9ivg, assembly 1, front view.
GLP-1(9-36) in PDB entry 9ivg, assembly 1, side view.
GLP-1(9-36) in PDB entry 9ivg, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01275  
128246810121416182022242628
 
1020EGTFTSDVSSYLEGQAAKEFIAWLVKGR
UniProt
P01275
Chains
Secondary structure
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

Glucagon-like peptide 1 receptor
Chain: R
Length: 440 amino acids
Theoretical weight: 50.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P43220 (Residues: 24-463; Coverage: 100%)
Gene name: GLP1R
Pfam:
Glucagon-like peptide 1 receptor in PDB entry 9ivg, assembly 1, front view.
Glucagon-like peptide 1 receptor in PDB entry 9ivg, assembly 1, side view.
Glucagon-like peptide 1 receptor in PDB entry 9ivg, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P43220  
144050100150200250300350400
 
200400
UniProt
P43220
Chains
Secondary structure
Interaction interfaces
Molecule details ›

Search similar proteins

Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 361 amino acids
Theoretical weight: 41.88 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63096 (Residues: 1-19, 61-181, 229-242; Coverage: 41%)
  • Canonical: P63092 (Residues: 27-67, 205-251, 266-394; Coverage: 55%)
    • nullnull
Gene names: GNAI1, GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 9ivg, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 9ivg, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 9ivg, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P63096   P63092  
136150100150200250300350
 
100200300
UniProt
P63096
P63092
Chains
Secondary structure
Interaction interfaces
Molecule details ›

Search similar proteins

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 345 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 9ivg, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 9ivg, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 9ivg, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P62873  
134550100150200250300
 
100200300
UniProt
P62873
Chains
Secondary structure
Interaction interfaces
Molecule details ›

Search similar proteins

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 70 amino acids
Theoretical weight: 7.73 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P59768 (Residues: 2-71; Coverage: 99%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 9ivg, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 9ivg, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 9ivg, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P59768  
170510152025303540455055606570
 
204060ASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
UniProt
P59768
Chains
Secondary structure
Interaction interfaces
Molecule details ›

Search similar proteins

Nanobody-35
Chain: N
Length: 140 amino acids
Theoretical weight: 15.34 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Nanobody-35 in PDB entry 9ivg, assembly 1, front view.
Nanobody-35 in PDB entry 9ivg, assembly 1, side view.
Nanobody-35 in PDB entry 9ivg, assembly 1, top view.
1140102030405060708090100110120130140
 
50100
Chains
Chain F (auth N)
Secondary structure
Interaction interfaces
Molecule details ›

Search similar proteins

Quick links