Structure analysis

Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex

Electron Microscopy
3Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 54158.58 Å2
Buried surface area: 14577.09 Å2
Dissociation area: 2,568.41 Å2
Dissociation energy (ΔGdiss): -5.38 kcal/mol
Dissociation entropy (TΔSdiss): 27.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-283458

Macromolecules

Chain: P
Length: 28 amino acids
Theoretical weight: 3.09 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
128246810121416182022242628
 
1020EGTFTSDVSSYLEGQAAKEFIAWLVKGR
UniProt
P01275
Chains
Secondary structure
Interaction interfaces
Sequence conservation
Variants

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Chain: R
Length: 440 amino acids
Theoretical weight: 50.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
144050100150200250300350400
 
200400RPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt
P43220
Chains
Secondary structure
Interaction interfaces
Sequence conservation
Variants

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Chain: A
Length: 361 amino acids
Theoretical weight: 41.88 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
136150100150200250300350
 
100200300MGCTLSAEDKAAVERSKMIEKQLQKDKQVYRATHRLLLLGADNSGKSTIVKQMRIYHVNGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQEALNDFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCSVDTENARRIFNDCRDIIQRMHLRQYELL
UniProt
P63096
P63092
Chains
Secondary structure
Interaction interfaces
Sequence conservation

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Chain: B
Length: 345 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
134550100150200250300
 
100200300MGSLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
UniProt
P62873
Chains
Secondary structure
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Chain: G
Length: 70 amino acids
Theoretical weight: 7.73 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
170510152025303540455055606570
 
204060ASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
UniProt
P59768
Chains
Secondary structure
Interaction interfaces
Sequence conservation

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Chain: N
Length: 140 amino acids
Theoretical weight: 15.34 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
1140102030405060708090100110120130140
 
50100MAQVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTVSSHHHHHHEPEA
Chains
Chain F (auth N)
Secondary structure
Interaction interfaces
Sequence conservation

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