Featured Structure Articles

Structure of a left-handed DNA G-quadruplex.

Structure of a left-handed DNA G-quadruplex.

PDB entry: 4u5m The iconic double helical structure of B-form DNA needs no introduction, but DNA can take on several different structures too. G-quadruplex DNA is formed from guanine-rich DNA sequences which are found in the telomeres. 

Structure of an allergen from surgical gloves

Structure of an allergen from surgical gloves

PDB 4wp4:

Cryo-EM structure of the Dark apoptosome.

Cryo-EM structure of the Dark apoptosome.

EMDB EMD-2871: The apoptosome, which comprises 16 molecules of the Dark protein, facilitates autocatalytic activation of caspase, which starts the process of apoptosis, or cell death.

FGFR1 with an inhibitor

FGFR1 with an inhibitor

PDB 4ux0: Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. Structures released on 25th February describe insights underpinning the impact of mutations on these proteins on drug efficacy.

Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Ramp2 Response Element.

Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Ramp2 Response Element.

PDB 4cn2: