Receptor tyrosine-protein kinase erbB-2

Gene:

ERBB2 Enzyme: EC 2.7.10.1 This enzyme has known catalytic activity involved in reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) Disease Glioma: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

HER2, MLN19, NEU, NGL

Uniprot:

P04626go to UniProt

Biological function:

In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growthgo to UniProt

Representative structures for UniProt P04626

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PDB 7mn5 chain C (observed residues)
PDB 7mn5 chain C (observed residues)
PDB 7mn5 chain C (observed residues)
PDB 7mn5 chain C (observed residues)
PDB 7mn5 chain C (observed residues)
PDB 7mn5 chain C (observed residues)
PDB 7mn5 chain C (observed residues)
PDB 7mn5 chain C (observed residues)
PDB 4nnd chain F (observed residues)
PDB 4nnd chain F (observed residues)
PDB 2l4k chain B (observed residues)
PDB 2l4k chain B (observed residues)
PDB 5tqs chain H (observed residues)
PDB 5tqs chain H (observed residues)
PDB 4gfu chain B (observed residues)
PDB 4gfu chain B (observed residues)

PDB chain shown: 7mn5 C go to PDBe

UniProt residues 1 - 1029

Coverage: 46%

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55
Structures

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16
Ligands

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18
Interactions

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5
Similarity

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878
Publications

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