Endothelin-1

Gene:

EDN1 Disease Question mark ears, isolated: An auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus.... [click for more]

Organism:

Homo sapiens (Human)

Uniprot:

P05305go to UniProt

Biological function:

Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with ... [show more]go to UniProt

Representative structure for UniProt P05305

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PDB 1t7h chain B (observed residues)
PDB 1t7h chain B (observed residues)

PDB chain shown: 1t7h B go to PDBe

UniProt residues 51 - 68

Coverage: 8%

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17
Structures

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0
Ligands


6
Interactions

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0
Similarity


86
Publications

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