All-trans-retinol dehydrogenase [NAD(+)] ADH4

Gene:

ADH4 Enzyme: EC 1.1.1.105 This enzyme has known catalytic activity involved in reaction: 1,4-benzoquinone + NADH + H(+) = hydroquinone + NAD(+)

Organism:

Homo sapiens (Human)

Synonyms:

ADH2

Uniprot:

P08319go to UniProt

Biological function:

Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444)go to UniProt

Representative structure for UniProt P08319

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PDB 3cos chain A (observed residues)
PDB 3cos chain A (observed residues)

PDB chain shown: 3cos A go to PDBe

UniProt residues 1 - 380

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