Guanine nucleotide-binding protein G(o) subunit alpha

Gene:

GNAO1 Enzyme: EC 3.6.5.- This enzyme has known catalytic activity involved in reaction: GTP + H2O = GDP + phosphate + H(+) Disease Developmental and epileptic encephalopathy 17: A severe neurologic disorder characterized by onset of intractable seizures in the first weeks or months of life and usually associated with EEG abnormalities. Affected infants have very poor psychomotor development and may have brain abnormalities, such as cerebral atrophy or thin corpus callosum... [click for more]

Organism:

Homo sapiens (Human)

Uniprot:

P09471go to UniProt

Biological function:

Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha ... [show more]go to UniProt

Representative structure for UniProt P09471

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PDB 9f33 chain A (observed residues)
PDB 9f33 chain A (observed residues)
PDB 9f33 chain A (observed residues)
PDB 9f33 chain A (observed residues)
PDB 9f33 chain A (observed residues)
PDB 9f33 chain A (observed residues)

PDB chain shown: 9f33 A go to PDBe

UniProt residues 1 - 354

Coverage: 61%

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57
Structures

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31
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32
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322
Similarity

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167
Publications

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