Neurogenic locus notch homolog protein 1

Gene:

NOTCH1 Disease Aortic valve disease 1: A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

TAN1

Uniprot:

P46531go to UniProt

Biological function:

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial ... [show more]go to UniProt

Representative structures for UniProt P46531

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PDB 5fm9 chain A (observed residues)
PDB 5fm9 chain A (observed residues)
PDB 4cud chain A (observed residues)
PDB 4cud chain A (observed residues)
PDB 9b3n chain A (observed residues)
PDB 9b3n chain A (observed residues)
PDB 3i08 chain A (observed residues)
PDB 3i08 chain A (observed residues)
PDB 3i08 chain B (observed residues)
PDB 3i08 chain B (observed residues)
PDB 8orz chain A (observed residues)
PDB 8orz chain A (observed residues)
PDB 3v79 chain F (observed residues)
PDB 3v79 chain F (observed residues)
PDB 3v79 chain A (observed residues)
PDB 3v79 chain A (observed residues)
PDB 3v79 chain A (observed residues)
PDB 3v79 chain A (observed residues)
PDB 3v79 chain A (observed residues)
PDB 3v79 chain A (observed residues)

PDB chain shown: 5fm9 A go to PDBe

UniProt residues 140 - 294

Coverage: 6%

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29
Structures

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15
Ligands

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7
Interactions

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Annotations

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3
Similarity

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299
Publications

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