Cyclin-H

Gene:

CCNH

Organism:

Homo sapiens (Human)

Uniprot:

P51946go to UniProt

Biological function:

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of ... [show more]go to UniProt

Representative structure for UniProt P51946

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PDB 8p77 chain B (observed residues)
PDB 8p77 chain B (observed residues)
PDB 8p77 chain B (observed residues)
PDB 8p77 chain B (observed residues)

PDB chain shown: 8p77 B go to PDBe

UniProt residues 1 - 323

Coverage: 86%

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37
Structures

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22
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7
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158
Similarity

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97
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