Peregrin

Gene:

BRPF1 Disease Intellectual developmental disorder with dysmorphic facies and ptosis: An autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development, intellectual disability, delayed language, and facial dysmorphisms, most notably ptosis. Additional features may include poor growth, hypotonia, and seizures... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

BR140

Uniprot:

P55201go to UniProt

Biological function:

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate ... [show more]go to UniProt

Representative structures for UniProt P55201

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PDB 6u04 chain A (observed residues)
PDB 6u04 chain A (observed residues)
PDB 6u04 chain A (observed residues)
PDB 6u04 chain A (observed residues)
PDB 6u04 chain A (observed residues)
PDB 6u04 chain A (observed residues)
PDB 4uye chain B (observed residues)
PDB 4uye chain B (observed residues)
PDB 2x35 chain A (observed residues)
PDB 2x35 chain A (observed residues)

PDB chain shown: 6u04 A go to PDBe

UniProt residues 271 - 454

Coverage: 15%

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66
Structures

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61
Ligands

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6
Interactions

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3
Similarity

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Publications