- Display observed secondary structure variance per amino acid residue
Guanine nucleotide-binding protein G(i) subunit alpha-1
GNAI1 Enzyme: EC 3.6.5.- This enzyme has known catalytic activity involved in reaction: GTP + H2O = GDP + phosphate + H(+) Disease Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities: An autosomal dominant disorder characterized by global developmental delay, impaired intellectual development, delayed or absent speech, hypotonia, behavioral abnormalities, and epilepsy that ranges from self-limiting to intractable. More variable features include non-specific dysmorphic facial features, distal skeletal anomalies, and brain imaging abnormalities... [click for more]
Homo sapiens (Human)
P63096go to UniProt
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883). The alpha chain contains the guanine ... [show more]go to UniProt
Representative structure for UniProt P63096
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PDB chain shown: 7trp E go to PDBe
UniProt residues 1 - 354
Coverage: 64%