Breast cancer type 2 susceptibility protein homolog

Gene:

Brca2

Organism:

Mus musculus (Mouse)

Synonyms:

Fancd1

Uniprot:

P97929go to UniProt

Biological function:

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which ... [show more]go to UniProt

Representative structure for UniProt P97929

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PDB 1mje chain C (observed residues)
PDB 1mje chain C (observed residues)
PDB 1mje chain C (observed residues)
PDB 1mje chain C (observed residues)
PDB 1mje chain C (observed residues)
PDB 1mje chain C (observed residues)

PDB chain shown: 1mje C go to PDBe

UniProt residues 2378 - 3113

Coverage: 18%

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152
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