Growth hormone-releasing hormone receptor

Gene:

GHRHR Disease Growth hormone deficiency, isolated, 4: An autosomal recessive deficiency of growth hormone leading to early and severe growth failure and short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy... [click for more]

Organism:

Homo sapiens (Human)

Uniprot:

Q02643go to UniProt

Biological function:

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretiongo to UniProt

Representative structure for UniProt Q02643

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PDB 7cz5 chain A (observed residues)
PDB 7cz5 chain A (observed residues)
PDB 7cz5 chain A (observed residues)
PDB 7cz5 chain A (observed residues)

PDB chain shown: 7cz5 A go to PDBe

UniProt residues 23 - 405

Coverage: 64%

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