Angiotensin-converting enzyme 2

Gene:

Ace2 Enzyme: EC 3.4.17.23 This enzyme has known catalytic activity involved in reaction: apelin-17 + H2O = apelin-16 + L-phenylalanine

Organism:

Mus musculus (Mouse)

Uniprot:

Q8R0I0go to UniProt

Biological function:

Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor ... [show more]go to UniProt

Representative structure for UniProt Q8R0I0

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PDB 8dma chain B (observed residues)
PDB 8dma chain B (observed residues)

PDB chain shown: 8dma B go to PDBe

UniProt residues 1 - 615

Coverage: 74%

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23
Structures

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6
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23
Similarity

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50
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