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Cryo-EM structure of human NCX1 in complex with SEA0400
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8sgi
Q-score: 0.553
To Be Published
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
- Fab light chain (21 kDa, Protein from Mus musculus)
- 2-{4-[(2,5-difluorophenyl)methoxy]phenoxy}-5-ethoxyaniline (371 Da, Ligand)
- Antibody fab fragment (Complex from Mus musculus)
- Human cardiac sodium calcium exchanger ncx1 in complex with sea0400 (Complex from Homo sapiens)
- Fab heavy chain (26 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Human ncx1-sea0400 in complex with antibody fab fragment (Complex)
- Water (18 Da, Ligand)
- Calcium ion (40 Da, Ligand)
CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628
Resolution: 4.36 Å
EM Method: Single-particle
Fitted PDBs: 9axa
Q-score: 0.277
Ryan MB, Quade B, Schenk N, Fang Z, Zingg M, Cohen SE, Swalm BM, Li C, Ozen A, Ye C, Ritorto MS, Huang X, Dar AC, Han Y, Hoeflich KP, Hale M, Hagel M
Cancer Discov (2024) [ Pubmed: 38588399 DOI: doi:10.1158/2159-8290.CD-24-0139 ]
- 14-3-3 protein sigma (27 kDa, Protein from Homo sapiens)
- N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2h-1-benzopyran-3-yl}methyl)pyridin-2-yl]-n'-methylsulfuric diamide (488 Da, Ligand)
- Craf/mek/14-3-3 complex with nst-628 (Complex from Homo sapiens)
- Gst26/craf chimera (64 kDa, Protein from Homo sapiens)
- Dual specificity mitogen-activated protein kinase kinase 1 (43 kDa, Protein from Homo sapiens)
Activated CRAF/MEK heterotetramer from focused refinement of CRAF/MEK/14-3-3 complex
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 9axc
Q-score: 0.335
Ryan MB, Quade B, Schenk N, Fang Z, Zingg M, Cohen SE, Swalm BM, Li C, Ozen A, Ye C, Ritorto MS, Huang X, Dar AC, Han Y, Hoeflich KP, Hale M, Hagel M
Cancer Discov (2024) [ Pubmed: 38588399 DOI: doi:10.1158/2159-8290.CD-24-0139 ]
- Activated craf/mek1 heterotetramer complex from focused refinement (Complex from Homo sapiens)
- Dual specificity mitogen-activated protein kinase kinase 1 (43 kDa, Protein from Homo sapiens)
- Gst26/craf chimera (64 kDa, Protein from Homo sapiens)
- N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2h-1-benzopyran-3-yl}methyl)pyridin-2-yl]-n'-methylsulfuric diamide (488 Da, Ligand)
Cryo-EM structure of OSCA1.2-liposome-inside-in open state
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xaj
Q-score: 0.42
Cryo-EM structure of OSCA1.2-liposome-inside-out closed state
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8xng
Q-score: 0.398
Cryo-EM structure of OSCA3.1-1.1ver(Y367N-G454S-Y458I)-open/open state
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8xry
Q-score: 0.421
Cryo-EM structure of OSCA3.1-1.1ver(Y367N-G454S-Y458I)-open/'desensitized' state
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8xs0
Q-score: 0.376
Cryo-EM structure of OSCA1.2-DOPC-1:20-contracted1 state
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8xs4
Q-score: 0.48
Cryo-EM structure of OSCA1.2-DOPC-1:20-contracted2 state
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8xs5
Q-score: 0.456
Cryo-EM structure of OSCA1.2-DOPC-1:20-expanded state
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8xvx
Q-score: 0.473