The Electron Microscopy Data Bank (EMDB) is a public repository for cryogenic-sample Electron Microscopy (cryoEM) volumes and representative tomograms of macromolecular complexes and subcellular structures. It covers a variety of techniques, including single-particle analysis, helical reconstruction, electron tomography, subtomogram averaging, and electron crystallography. More...
As of 16 October 2024, EMDB contains 39403 entries (latest entries, trends).
EMDB News
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06 January 2024: We are delighted to share that EMDB has officially been elevated to a Core Data Resource by ELIXIR, recognising it as a European data resource of fundamental importance to the wider life-science community and the long-term preservation of biological data.
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22 November 2023: We are happy to share the most recent version of the EMDB Nucleic Acids Research paper. The paper describes recent developments and future plans of the EMDB in the context of the worldwide Protein Data Bank. Check it out now! https://doi.org/10.1093/nar/gkad1019
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(Show all)CryoEM structure of the type IV pilin PilA5 from Thermus thermophilus
CryoEM structure of the fragment-3 (2061-2397) in the grappling hook protein A (GhpA) in the bacterium Aureispira sp. CCB-QB1
Cryo-EM structure of Spinacia oleracea cytochrome b6f complex with water molecules at 1.94 A resolution
Cryo-EM structure of DHS-ERK2 complex with 1:1 stoichiometry refined in C1 symmetry
CryoEM structure of the base (4151-5009) in the grappling hook protein A (GhpA) in the bacterium Aureispira sp. CCB-QB1
Cryo-EM structure of the BcsE2F2 regulatory subcomplex from the E. coli Bcs macrocomplex for cellulose secretion (local refinement)
CryoEM structure of the fragment-2 (2892-3236) in the grappling hook protein A (GhpA) in the bacterium Aureispira sp. CCB-QB1
Cryo-EM structure of DHS-ERK2 complex with 1:4 stoichiometry refined in C1 symmetry
Cryo-EM structure of the third of three possible DHS-ERK2 complexes with 1:2 stoichiometry refined in C1 symmetry
Structure of a Ca2+ bound phosphoenzyme intermediate in the inward-to-outward transition of Ca2+-ATPase 1 from Listeria monocytogenes
40S-bound human SKI238 complex in the open state (Gatekeeping module)
CryoEM structure of the neck (1403-2314) in the grappling hook protein A (GhpA) in the bacterium Aureispira sp. CCB-QB1
Cryo-EM structure of the c-di-GMP-saturated Bcs macrocomplex (BcsABR2Q2E2F2G3) for cellulose secretion of E. coli (filtered to 6A)
CryoEM structure of the fragment-1 (3402-3733) in the grappling hook protein A (GhpA) in the bacterium Aureispira sp. CCB-QB1
Scalable protein design using hallucination in a relaxed sequence space
Focussed refinement on alpha-Latrotoxin (Pore-state), chainC, residues 650-1195
Cryo-EM structure of the 'crown'less Bcs macrocomplex for E. coli cellulose secretion in non-saturating c-di-GMP (local)
Cryo-EM structure of the c-di-GMP-saturated 'crown'less Bcs macrocomplex for cellulose secretion in E. coli
CryoEM structure of the fragment-5 (2393-2807) in the grappling hook protein A (GhpA) in the bacterium Aureispira sp. CCB-QB1
Cryo-EM structure of the c-di-GMP non-saturated Bcs macrocomplex (BcsABR2Q2E2F2G3) for cellulose secretion of E. coli (filtered to 7A)
(N3Occluded Composite Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Overall map for human RANBP2/RAN(GTP)/SUMO1-RANGAP1/UBC9/CRM1/RAN(GTP) complex where SUMO1-RANGAP1/UBC9 was present
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist JNJ47965567
VIR-7229 Fab fragment bound the BA.2.86 spike trimer (global refinement)
(V17) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
(N3Shifted Local CORE2 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Structure of the P1B7 antibody bound to the Sotorasib-modified KRas G12C peptide presented by the A*03:01 MHC I complex
Apoferritin structure determined using laser phase contrast TEM (laser-off)
Local refinement map of mink RyR3 in open conformation bound to Ca2+/ATP/caffeine using mask 4 (TMD/CTD)
Local refinement map of mink RyR3 in closed conformation using mask 1 (FKBP12.6/NTD/Nsol/SPRY/Repeat1&2)
Carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) pentamer from Methanosarcina thermophila
The CryoEM structure of the high affinity Carbon monoxide dehydrogenase from Mycobacterium smegmatis
(N3 Shifted Local ABC2 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Subtomogram averaged eEF1alpha hibernating state of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes
Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX
Rubisco structure determined using laser phase contrast TEM (laser-on)
Subtomogram averaged eEF2 hibernating-1 state of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes
Consensus map of mink RyR3 in open conformation bound to Ca2+/ATP/caffeine
Cryo-EM structure of Mycobacterium smegmatis ATP synthase rotational state 1 in inverted membrane vesicles
Human RANBP2/RAN(GTP)/RANGAP1-SUMO1/UBC9/CRM1/RAN(GTP) - composite map and model
Archaeal highly thermostable GH35 family beta-galactosidase from Desulfurococcus amyloliticus
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160
Rubisco structure determined using laser phase contrast TEM (laser-off)
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A839977
(N3Occluded Consensus Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Structure of full-length gelsolin bound to the barbed end of F-actin
Constituent EM map: Focused refinement BSol2 of the Structure of human RyR2-S2808D in the closed state in the presence of ARM210
Apoferritin structure solved using a laser phase plate TEM (laser-on)
(N3Occluded Local CORE1 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Focused refinement map on RanGAP1 C-terminal domain-SUMO1/UBC9/RANBP2 E3 domain for human RANBP2/RAN(GTP)/SUMO1-RANGAP1/UBC9/CRM1/RAN(GTP) complex where SUMO1-RANGAP1/UBC9 was present
Pseudomonas phage Pa193 neck and extended tail (collar, gateway, tail tube, and sheath proteins)
(N3Occluded Local ABC1 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Lineage IV Lassa virus glycoprotein (Josiah) in complex with polyclonal antibody (Base-2 epitope) from rabbit 190
(N3Shifted Consensus Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Focused refinement map on RANGAP1 GAP domain from human RANBP2/RAN(GTP)/SUMO1-RANGAP1/UBC9/CRM1/RAN(GTP) complex
Human RANBP2/SUMO1-RANGAP1/RAN(GTP)/UBC9/CRM1/RAN(GTP) complex - overall map
Local refinement map of mink RyR3 in closed conformation using mask 3 (Bsol/Repeat3&4)
GPCysRRLL-I53-50A in complex with rabbit 188 wk 30 base epitope pAbs
Local refinement map of mink RyR3 in open conformation bound to Ca2+/ATP/caffeine using mask 2 (Jsol/Csol/Bsol)
GPCysRRLL-I53-50A in complex with rabbit 189 wk 18 GPC-A and base epitope pAbs
Cryo-EM Structures of Full-Length Integrin alphaIIbbeta3 in Native Lipids Complexed with Tirofiban
GPCysRRLL-I53-50A in complex with rabbit 191 wk 30 base epitope pAbs
Structure of gelsolin domains G1-G3 bound to the barbed end of F-actin
Composite map of mink RyR3 in open conformation bound to Ca2+/ATP/caffeine
Local refinement map of mink RyR3 in open conformation bound to Ca2+/ATP/caffeine using mask 1 (FKBP12.6/NTD/Nsol/SPRY/Repeat1&2)
Pseudomonas phage Pa193 5-fold vertex (capsid, decorating, and scaffolding proteins)
Carbon monoxide dehydrogenase (CODH) from Methanosarcina thermophila, specimen prepared on chameleon plunger
Carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) hexamer from Methanosarcina thermophila
(Composite) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Cryo-EM structures of full-length integrin alphaIIbbeta3 in native lipids complexed with modified tirofiban
Focused refinement map on CRM1/RAN(GTP) from human RANBP2/RAN(GTP)/SUMO1-RANGAP1/UBC9/CRM1/RAN(GTP) complex
Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Translocating a Portion of a Branched-Degron DHFR Substrate
Local refinement map of mink RyR3 in closed conformation using mask 4 (TMD/CTD)
Overall map for the RANBP2 RBD4/RAN(GTP)/RANGAP1 GAP domain from human RANBP2/RAN(GTP)/SUMO1-RANGAP1/UBC9/CRM1/RAN(GTP) complex
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist methyl blue
Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA Substrate Bound with MTX
GPCysRRLL-I53-50A in complex with rabbit 190 wk 30 fusion peptide and base epitope pAbs
(N3Shifted Composite Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
(N3Occluded Local ABC2 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
GPCysRRLL-I53-50A in complex with rabbit 189 wk 30 GPC-A and base epitope pAbs
VIR-7229 Fab fragment bound the SARS-CoV-2 BA.2.86 spike trimer (local refinement of the BA 2.86 RBD/VIR-7229 VHVL)
Focused refinement map on RANBP2 RBD4/RAN(GTP) from human RANBP2/RAN(GTP)/SUMO1-RANGAP1/UBC9/CRM1/RAN(GTP) complex
Cryo-EM structure of Mycobacterium smegmatis ATP synthase rotational state 1 in inverted membrane vesicles - F1 region
Local refinement of F-actin barbed end subunits B-3, B-4, and B-5
(Local CORE2) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
GPCysRRLL-I53-50A in complex with rabbit 187 wk 30 GPC-A, base, and fusion peptide epitope pAbs
Local refinement map of mink RyR3 in closed conformation using mask 2 (Jsol/Csol/Bsol)
Local refinement of G1-G3 and F-actin barbed end subunits B-0 and B-2
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056
GPCysRRLL-I53-50A in complex with rabbit 187 wk 18 GPC-A, base, and fusion peptide epitope pAbs
(Local ABC2) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A438079
Carbon monoxide dehydrogenase (CODH) from Methanosarcina thermophila, specimen prepared on blot plunger
Mitochondrial fission site in neurons at the post fission state 2
Local refinement map of mink RyR3 in open conformation bound to Ca2+/ATP/caffeine using mask 3 (Bsol/Repeat3&4)
GPCysRRLL-I53-50A in complex with rabbit 192 wk 30 base and fusion peptide epitope pAbs
(N3Shifted Local CORE1 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Focused refinement map for RanGAP1 C-terminal domain-SUMO1/UBC9/RANBP2/CRM1/RAN(GTP) for human RANBP2/RAN(GTP)/SUMO1-RANGAP1/UBC9/CRM1/RAN(GTP) complex where SUMO1-RANGAP1/UBC9 was present
(N3Shifted Local ABC2 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Consensus map of full-length gelsolin bound to the barbed end of F-actin
Subtomogram averaged rotated-1 PRE back rolled state of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes
Cryo-EM structure of the human ATP-binding cassette transporter: ABCG2 mutant (E211Q)
Cryo-EM structure of PTH-PTH1R-Gq complex (upright state; receptor focused refinement)
Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo
Cryo-EM structure of SARS-CoV-2 XBB.1.5 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies
Cryo-EM structure of human ABC Transporter ABCC2 in apo form from Biortus
Cryo-EM structure of PTH-PTH1R-Gq complex (upright state; consensus refinement)
MPOX E5 hexamer AMP-PNP and ssDNA bound form with clear primase domain
Cryo-EM structure of the tetrameric SPARSA gRNA-ssDNA-NAD+ complex
Cryo-EM structure of SARS-CoV-2 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies
Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo
Cryo-EM structure of PTH-PTH1R-Gq complex (tilted state; focused refinement map)
Cryo-EM structure of PTH-PTH1R-Gq complex (tilted state; consensus refinement map)
Cryo-EM structure of human ABC Transporter ABCC2 with E1462Q mutation from Biortus
Cryo-EM structure of the human TRPC1/C4 heteromer in complex with Pico145
Cryo-EM map of SARS-CoV-2 alpha variant spike protein in complex with raccoon dog ACE2
Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with raccoon dog ACE2
Cryo-EM structure of a T=1 VLP of RHDV GI.2 with N-terminal 1-37 residues truncated
Scalable protein design using hallucination in a relaxed sequence space
Beta-galactosidase from Bacillus circulans conformational state 1
Cryo-EM structure of P5A-ATPase CtSpf1 (E1P state with cytosolic-feature bound)
Cryo-EM structure of the first of three possible DHS-ERK2 complexes with 1:2 stoichiometry refined in C2 symmetry
Beta-galactosidase from Bacillus circulans conformational state 2
Cryo-EM structure of the second of three possible DHS-ERK2 complexes with 1:2 stoichiometry refined in C1 symmetry
CryoEM structure of the fragment-4 (4074-4421) in the grappling hook protein A (GhpA) in the bacterium Aureispira sp. CCB-QB1
Cryo-EM structure of P5A-ATPase CtSpf1 ( E2P state with endogenous cargo bound)
Cryo-EM structure of Spinacia oleracea cytochrome b6f complex with inhibitor DBMIB bound at plastoquinol oxidation site
Cryo-EM structure of Spinacia oleracea cytochrome b6f with decylplastoquinone bound at plastoquionol reduction site
Cryo-EM structure of the c-di-GMP-free synthase:pEtN transferase complex (BcsA-Bct-G3) from the E. coli cellulose secretion macrocomplex
Focussed refinement on alpha-Latrotoxin (Pore-state), chainD, residues 650-1195
REEL analysis reconstructions of lumbricus terrestris erythrocruorin (worm hemoglobin)
Cryo-EM structure of the BcsEFRQ regulatory subcomplex for E. coli cellulose secretion in non-saturating c-di-GMP (local)
CryoEM structure of the fragment-6 (3571-4078) in the grappling hook protein A (GhpA) in the bacterium Aureispira sp. CCB-QB1
Cryo-EM structure of the c-di-GMP-bound synthase:pEtN transferase complex (BcsA-Bct-G3) from the E. coli cellulose secretion macrocomplex
Focussed refinement on alpha-Latrotoxin, ChainB, residues 796-1195
Focussed refinement on alpha-Latrotoxin (Pore-state), chainB, residues 650-1195
Cryo-EM structure of the first of three possible DHS-ERK2 complexes with 1:2 stoichiometry refined in C1 symmetry
Focussed refinement on alpha-Latrotoxin, ChainA-D, residues 105-788
Cryo-EM structure of P5A-ATPase CtSpf1 (E1P-ADP state with membranous-feature bound)
Cryo-EM structure of the third of three possible DHS-ERK2 complexes with 1:2 stoichiometry refined in C2 symmetry
Cryo-EM structure of the second of three possible DHS-ERK2 complexes with 1:2 stoichiometry refined in C2 symmetry
Cytoplasmic Fission Yeast Ribosome Tethered to the Outer Mitochondrial Membrane
Cryo-EM structure of the BcsB hexameric crown from the E. coli cellulose secretion macrocomplex
Cryo-EM structure of DHS-ERK2 complex with 1:4 stoichiometry refined in D2 symmetry
CryoEM structure of the type IV pilin PilA4 from Thermus thermophilus
Structure of V-ATPase obtained from isolated mouse synaptic vesicles
Focussed refinement on alpha-Latrotoxin, ChainA, residues 796-1195
Focussed refinement on alpha-Latrotoxin (Pore-state), chainA, residues 650-1195
Cryo-EM structure of P5A-ATPase CtSpf1 (E2.Pi state with endogenous helix cargo bound)
Focussed refinement on alpha-Latrotoxin, ChainC, residues 796-1195
Cryo-EM structure of DHS-ERK2 complex with 1:3 stoichiometry refined in C1 symmetry
Focussed refinement on alpha-Latrotoxin, ChainD, residues 796-1195