yeast cytoplasmic exosome-Ski2 complex degrading a RNA substrate
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8qcf
Q-score: 0.603
Keidel A, Kogel A, Reichelt P, Kowalinski E, Schafer IB, Conti E
Mol Cell (2023) 83 pp. 4093-4105.e7 [ DOI: doi:10.1016/j.molcel.2023.09.037 Pubmed: 37879335 ]
- Exosome complex component rrp45 (34 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component rrp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex exonuclease dis3 (114 kDa, Protein from Saccharomyces cerevisiae)
- Antiviral helicase ski2 (117 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component rrp43 (44 kDa, Protein from Saccharomyces cerevisiae)
- Yeast cytoplasmic exosome-ski2 complex degrading a rna substrate (Complex from Saccharomyces cerevisiae)
- Exosome complex component rrp40 (26 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component ski6 (27 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component csl4 (31 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component rrp42 (29 kDa, Protein from Saccharomyces cerevisiae)
- Rrp46 isoform 1 (24 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component mtr3 (27 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Rna (5'hairpin 60u) (24 kDa, RNA from Saccharomyces cerevisiae)
- Superkiller protein 7 (39 kDa, Protein from Saccharomyces cerevisiae)
CryoEM structure of a S. Cerevisiae Ski238 complex bound to RNA
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8q9t
Q-score: 0.552
Keidel A, Kogel A, Reichelt P, Kowalinski E, Schafer IB, Conti E
Mol Cell (2023) 83 pp. 4093-4105.e7 [ Pubmed: 37879335 DOI: doi:10.1016/j.molcel.2023.09.037 ]
- Ski238 polyu rna (Complex from Saccharomyces cerevisiae)
- Rna (5'-r(p*up*up*up*u)-3') (9 kDa, RNA from Saccharomyces cerevisiae)
- Superkiller protein 3 (164 kDa, Protein from Saccharomyces cerevisiae)
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae)
- Antiviral helicase ski2 (146 kDa, Protein from Saccharomyces cerevisiae)
CryoEM structure of a S. Cerevisiae Ski2387 complex in the closed state bound to RNA
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8qca
Q-score: 0.572
Keidel A, Kogel A, Reichelt P, Kowalinski E, Schafer IB, Conti E
Mol Cell (2023) 83 pp. 4093- [ DOI: doi:10.1016/j.molcel.2023.09.037 Pubmed: 37879335 ]
- Rna (5'-r(p*up*up*up*u)-3') (9 kDa, RNA from Saccharomyces cerevisiae)
- Superkiller protein 7 (28 kDa, Protein from Saccharomyces cerevisiae)
- Ski2delarch387 polyu rna (Complex from Saccharomyces cerevisiae)
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae)
- Superkiller protein 3 (164 kDa, Protein from Saccharomyces cerevisiae)
- Antiviral helicase ski2 (146 kDa, Protein from Saccharomyces cerevisiae)
CryoEM structure of a S. Cerevisiae Ski2387 complex in an intermediate state bound to RNA
Keidel A, Kogel A, Reichelt P, Kowalinski E, Schafer IB, Conti E
Mol Cell (2023) 83 pp. 4093-4105.e7 [ Pubmed: 37879335 DOI: doi:10.1016/j.molcel.2023.09.037 ]
CryoEM structure of a S. Cerevisiae Ski2387 complex in the open state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8qcb
Q-score: 0.591
Keidel A, Kogel A, Reichelt P, Kowalinski E, Schafer IB, Conti E
Mol Cell (2023) 83 pp. 4093- [ Pubmed: 37879335 DOI: doi:10.1016/j.molcel.2023.09.037 ]
- Superkiller protein 3 (164 kDa, Protein from Saccharomyces cerevisiae)
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae)
- Antiviral helicase ski2 (146 kDa, Protein from Saccharomyces cerevisiae)
- Ski2delarch387 polyu rna (Complex from Saccharomyces cerevisiae)
- Superkiller protein 7 (28 kDa, Protein from Saccharomyces cerevisiae)
S.cerevisiae THO complex from endogenous nuclear mRNPs
Bonneau F, Basquin J, Steigenberger B, Schafer T, Schafer IB, Conti E
Genes Dev (2023) 37 pp. 505-517 [ DOI: doi:10.1101/gad.350630.123 Pubmed: 37399331 ]
- Tho complex dimer (Complex from Saccharomyces cerevisiae)
- Tho complex subunit hpr1 (Protein from Saccharomyces cerevisiae BY4741)
- Tho complex subunit mft1 (Protein from Saccharomyces cerevisiae BY4741)
- Protein tex1 (Protein from Saccharomyces cerevisiae BY4741)
- Tho complex subunit 2 (Protein from Saccharomyces cerevisiae BY4741)
- Tho complex subunit thp2 (Protein from Saccharomyces cerevisiae BY4741)
The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mqo
Q-score: 0.44
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: doi:10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - focused refinement. (209 kDa, Complex from Homo sapiens)
The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7mqr
Q-score: 0.304
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ Pubmed: 35289328 DOI: doi:10.1038/s41589-022-00981-0 ]
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - whole ectodomain. (209 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7mqs
Q-score: 0.232
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ Pubmed: 35289328 DOI: doi:10.1038/s41589-022-00981-0 ]
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - asymmetric conformation. (209 kDa, Complex from Homo sapiens)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7qdy
Q-score: 0.483
Kogel A, Keidel A, Bonneau F, Schafer IB, Conti E
Mol Cell (2022) 82 pp. 756- [ DOI: doi:10.1016/j.molcel.2022.01.009 Pubmed: 35120588 ]
- Helicase ski2w (137 kDa, Protein from Homo sapiens)
- Wd repeat-containing protein 61 (33 kDa, Protein from Homo sapiens)
- Tetratricopeptide repeat protein 37 (178 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*up*up*up*up*up*u)-3') (7 kDa, RNA from Homo sapiens)
- H.s. ski complex bound to rna (380 kDa, Complex from Homo sapiens)