Cryo-EM structure of SARS-CoV-2 ORF3a
Resolution: 2.08 Å
EM Method: Single-particle
Fitted PDBs: 7kjr
Q-score: 0.686
Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG
Nat Struct Mol Biol (2021) 28 pp. 573-582 [ DOI: doi:10.1038/s41594-021-00619-0 Pubmed: 34158638 ]
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Apolipoprotein a-i (24 kDa, Protein from Homo sapiens)
- Orf3a protein (32 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 protein 3a in lipid nanodiscs (62 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Water (18 Da, Ligand)
GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 6x18
Q-score: 0.563
Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D
Mol Cell (2020) 80 pp. 485- [ DOI: doi:10.1016/j.molcel.2020.09.020 Pubmed: 33027691 ]
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Glp-1 peptide hormone bound to glucagon-like peptide-1 (glp-1) receptor (120 kDa, Complex)
- Nanobody35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Glucagon (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 6x19
Q-score: 0.579
Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D
Mol Cell (2020) 80 pp. 485- [ DOI: doi:10.1016/j.molcel.2020.09.020 Pubmed: 33027691 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Nanobody35 (Complex from Lama glama)
- Nanobody35 (13 kDa, Protein from Lama glama)
- Chu-128:glp-1r:gs complex (120 kDa, Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- 3-{(1s)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4s)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1h-indazol-5-yl)-2-oxo-2,3-dihydro-1h-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5h-pyrazolo[4,3-c]pyridine-5-carbonyl}-1h-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4h)-one (885 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6x1a
Q-score: 0.522
Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D
Mol Cell (2020) 80 pp. 485- [ DOI: doi:10.1016/j.molcel.2020.09.020 Pubmed: 33027691 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Nanobody35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Pf-06882961:glp-1r:gs complex (120 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2s)-oxetan-2-yl]methyl}-1h-benzimidazole-6-carboxylic acid (555 Da, Ligand)
- Water (18 Da, Ligand)
- Nanobody35 (Complex from Lama glama)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6tko
Q-score: 0.417
Lee Y, Warne T, Nehme R, Pandey S, Dwivedi-Agnihotri H, Chaturvedi M, Edwards PC, Garcia-Nafria J, Leslie AGW, Shukla AK, Tate CG
Nature (2020) 583 pp. 862-866 [ DOI: doi:10.1038/s41586-020-2419-1 Pubmed: 32555462 ]
- Beta-arrestin-1 (Complex from Homo sapiens)
- Beta-1 adrenergic receptor (37 kDa, Protein from Meleagris gallopavo)
- Fab30 heavy chain (25 kDa, Protein from Phage display vector pTDisp)
- Beta-arrestin-1 (47 kDa, Protein from Homo sapiens)
- Formoterol-bound beta1-adrenoceptor coupled to beta-arrestin-1 stabilised by fab30. (133 kDa, Complex)
- ~{n}-[5-[(1~{r})-2-[[(2~{r})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide (344 Da, Ligand)
- Fab30 heavy chain (Complex from Phage display vector pTDisp)
- Fab30 light chain (23 kDa, Protein from Phage display vector pTDisp)
- Fab30 light chain (Complex from Phage display vector pTDisp)
- Beta-1 adrenergic receptor (Complex from Meleagris gallopavo)
Escherichia coli AGPase in complex with FBP.
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6r8b
Q-score: 0.536
Cifuente JO, Comino N, D'Angelo C, Marina A, Gil-Carton D, Albesa-Jove D, Guerin ME
bioRxiv (2020) [ DOI: doi:10.1101/2020.01.24.916759 ]
Escherichia coli AGPase in complex with AMP.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6r8u
Q-score: 0.559
Cifuente JO, Comino N, D'Angelo C, Marina A, Gil-Carton D, Albesa-Jove D, Guerin ME
bioRxiv (2020) [ DOI: doi:10.1101/2020.01.24.916759 ]
- Glucose-1-phosphate adenylyltransferase (48 kDa, Protein from Escherichia coli)
- Adp.glucose pyrophosphorylase in complex with the inhibitor amp (194 kDa, Complex from Escherichia coli)
- Adenosine monophosphate (347 Da, Ligand)
Escherichia coli AGPase in complex with FBP. Symmetry applied C2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6shj
Q-score: 0.521
Cifuente JO, Comino N, D'Angelo C, Marina A, Gil-Carton D, Albesa-Jove D, Guerin ME
Curr Res Struct Biol (2020) 2 pp. 89-103 [ DOI: doi:10.1016/j.crstbi.2020.04.005 Pubmed: 34235472 ]
Escherichia coli AGPase in complex with FBP. Symmetry C1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6shn
Q-score: 0.492
Cifuente JO, Comino N, D'Angelo C, Marina A, Gil-Carton D, Albesa-Jove D, Guerin ME
Curr Res Struct Biol (2020) 2 pp. 89-103 [ DOI: doi:10.1016/j.crstbi.2020.04.005 Pubmed: 34235472 ]
Escherichia coli AGPase in complex with AMP. Symmetry C2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6shq
Q-score: 0.532
Cifuente JO, Comino N, D'Angelo C, Marina A, Gil-Carton D, Albesa-Jove D, Guerin ME
Curr Res Struct Biol (2020) 2 pp. 89-103 [ DOI: doi:10.1016/j.crstbi.2020.04.005 Pubmed: 34235472 ]
- Glucose-1-phosphate adenylyltransferase (48 kDa, Protein from Escherichia coli)
- Adp.glucose pyrophosphorylase in complex with the inhibitor amp (194 kDa, Complex from Escherichia coli)
- Adenosine monophosphate (347 Da, Ligand)