Resolution: 3.94 Å
EM Method: Single-particle
Fitted PDBs: 8kci
Q-score: 0.356
Huang Y, Xue C, Bu R, Wu C, Li J, Zhang J, Chen J, Shi Z, Chen Y, Wang Y, Liu Z
Nat Commun (2024) 15 pp. 4811-4811 [ Pubmed: 38844452 DOI: doi:10.1038/s41467-024-49204-1 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-bound hmrp5 outward-open (Complex from Homo sapiens)
- Atp-binding cassette sub-family c member 5 (160 kDa, Protein from Homo sapiens)
Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8t50
Q-score: 0.385
Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8t4y
Q-score: 0.377
Cryo-EM Structure of SARS-CoV-2 BA.2 Spike protein in complex with BA7535
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 8h7l
Q-score: 0.377
Wang Y, Yan A, Song D, Duan M, Dong C, Chen J, Jiang Z, Gao Y, Rao M, Feng J, Zhang Z, Qi R, Ma X, Liu H, Yu B, Wang Q, Zong M, Jiao J, Xing P, Pan R, Li D, Xiao J, Sun J, Li Y, Zhang L, Shen Z, Sun B, Zhao Y, Zhang L, Dai J, Zhao J, Wang L, Dou C, Liu Z, Zhao J
Nat Commun (2024) 15 pp. 842-842 [ Pubmed: 38287016 DOI: doi:10.1038/s41467-024-45050-3 ]
- Ba7535 (Complex from Homo sapiens)
- Cryo-em structure of sars-cov-2 ba.2 spike protein in complex with ba7535 (Complex)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba7535 fab heavt chain (49 kDa, Protein from Homo sapiens)
- Sars-cov-2 ba.2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ba7535 fab light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of VTC complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ytj
Q-score: 0.485
Guan Z, Chen J, Liu R, Chen Y, Xing Q, Du Z, Cheng M, Hu J, Zhang W, Mei W, Wan B, Wang Q, Zhang J, Cheng P, Cai H, Cao J, Zhang D, Yan J, Yin P, Hothorn M, Liu Z
Nat Commun (2023) 14 pp. 718-718 [ DOI: doi:10.1038/s41467-023-36466-4 Pubmed: 36759618 ]
- Inositol hexakisphosphate (660 Da, Ligand)
- Vacuolar transporter chaperone 3 (100 kDa, Protein from Saccharomyces cerevisiae)
- Phosphate ion (94 Da, Ligand)
- Vtc complex (Complex from Saccharomyces cerevisiae)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Vacuolar transporter chaperone 4 (86 kDa, Protein from Saccharomyces cerevisiae)
- Vacuolar transporter chaperone 1 (15 kDa, Protein from Saccharomyces cerevisiae)
Cytoplasmic tail deleted HIV Env trimer in nanodisc
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 7sc5
Q-score: 0.394
Yang S, Hiotis G, Wang Y, Chen J, Wang JH, Kim M, Reinherz EL, Walz T
Nat Commun (2022) 13 pp. 6393-6393 [ DOI: doi:10.1038/s41467-022-34008-y Pubmed: 36302771 ]
- Transmembrane protein gp41 (24 kDa, Protein from HIV whole-genome vector AA1305#18)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 envelope glycoprotein env trimer (Cellular component from HIV whole-genome vector AA1305#18)
- Envelope glycoprotein gp120 (53 kDa, Protein from HIV whole-genome vector AA1305#18)
Cytoplasmic tail deleted HIV-1 Env bound with three 4E10 Fabs
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 7sd3
Q-score: 0.349
Yang S, Hiotis G, Wang Y, Chen J, Wang JH, Kim M, Reinherz EL, Walz T
Nat Commun (2022) 13 pp. 6393-6393 [ DOI: doi:10.1038/s41467-022-34008-y Pubmed: 36302771 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 gp145 bound with three 4e10 fabs (600 kDa, Complex from HIV whole-genome vector AA1305#18)
- Envelope glycoprotein gp120 (54 kDa, Protein from HIV whole-genome vector AA1305#18)
- 4e10 fab light chain (23 kDa, Protein from Homo sapiens)
- Transmembrane protein gp41 (19 kDa, Protein from HIV whole-genome vector AA1305#18)
- 4e10 fab heavy chain (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of DNMDP-induced PDE3A-SLFN12 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7eg1
Q-score: 0.549
Chen J, Liu N, Huang Y, Wang Y, Sun Y, Wu Q, Li D, Gao S, Wang HW, Huang N, Qi X, Wang X
Nat Commun (2021) 12 pp. 6204-6204 [ DOI: doi:10.1038/s41467-021-26546-8 Pubmed: 34707099 ]
- (4~{r})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{h}-pyridazin-6-one (305 Da, Ligand)
- Slfn12 (Complex)
- Cgmp-inhibited 3',5'-cyclic phosphodiesterase a (49 kDa, Protein from Homo sapiens)
- Dimer of pde3a-slfn12 heterodimer (Complex from Homo sapiens)
- Schlafen family member 12 (65 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Pde3a (Complex from Homo sapiens)
Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7eg0
Q-score: 0.487
Chen J, Liu N, Huang Y, Wang Y, Sun Y, Wu Q, Li D, Gao S, Wang HW, Huang N, Qi X, Wang X
Nat Commun (2021) 12 pp. 6204-6204 [ DOI: doi:10.1038/s41467-021-26546-8 Pubmed: 34707099 ]
- Slfn12 (Complex)
- Cgmp-inhibited 3',5'-cyclic phosphodiesterase a (49 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 6,7-bis(chloranyl)-3,5-dihydro-1h-imidazo[2,1-b]quinazolin-2-one (256 Da, Ligand)
- Pde3a (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Schlafen family member 12 (65 kDa, Protein from Homo sapiens)
- Dimer of pde3a-slfn12 heterodimer (Complex from Homo sapiens)
Cryo-EM structure of nauclefine-induced PDE3A-SLFN12 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7eg4
Q-score: 0.532
Chen J, Liu N, Huang Y, Wang Y, Sun Y, Wu Q, Li D, Gao S, Wang HW, Huang N, Qi X, Wang X
Nat Commun (2021) 12 pp. 6204-6204 [ DOI: doi:10.1038/s41467-021-26546-8 Pubmed: 34707099 ]
- Slfn12 (Complex)
- Cgmp-inhibited 3',5'-cyclic phosphodiesterase a (49 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Parvine (287 Da, Ligand)
- Pde3a (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Schlafen family member 12 (65 kDa, Protein from Homo sapiens)
- Dimer of pde3a-slfn12 heterodimer (Complex from Homo sapiens)