5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8fy8
Q-score: 0.519
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- 2-(5-methoxy-1h-indol-3-yl)-n,n-dimethylethan-1-amine (218 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8fye
Q-score: 0.53
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ Pubmed: 38720072 DOI: doi:10.1038/s41586-024-07403-2 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1h-indole (262 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8fyl
Q-score: 0.525
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ Pubmed: 38720072 DOI: doi:10.1038/s41586-024-07403-2 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide (441 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8fyt
Q-score: 0.544
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ Pubmed: 38720072 DOI: doi:10.1038/s41586-024-07403-2 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8fyx
Q-score: 0.545
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- Buspirone (385 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)