FSHR-Follicle stimulating hormone-compound 716340-Gs complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8i2g
Q-score: 0.363
Duan J, Xu P, Zhang H, Luan X, Yang J, He X, Mao C, Shen DD, Ji Y, Cheng X, Jiang H, Jiang Y, Zhang S, Zhang Y, Xu HE
Nat Commun (2023) 14 pp. 519-519 [ DOI: doi:10.1038/s41467-023-36170-3 Pubmed: 36720854 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fshr-follicle stimulating hormone-compound 716340-gs complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Follitropin subunit beta (12 kDa, Protein from Homo sapiens)
- Myristic acid (228 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- N-tert-butyl-n-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide (467 Da, Ligand)
- Chimera of guanine nucleotide-binding protein g(s) subunit alpha and guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (30 kDa, Protein from Homo sapiens)
- Follicle-stimulating hormone receptor (76 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
Follicle stimulating hormone receptor
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 8i2h
Q-score: 0.022
Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7bv1
Q-score: 0.485
Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE
Science (2020) 368 pp. 1499-1504 [ Pubmed: 32358203 DOI: doi:10.1126/science.abc1560 ]
- Rna-directed rna polymerase (109 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- The apo nsp12-nsp7-nsp8 complex (Complex from SARS bat coronavirus)
- Non-structural protein 8 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (10 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7bv2
Q-score: 0.607
Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE
Science (2020) 368 pp. 1499-1504 [ DOI: doi:10.1126/science.abc1560 Pubmed: 32358203 ]
- Magnesium ion (24 Da, Ligand)
- Non-structural protein 7 (10 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- [(2~{r},3~{s},4~{r},5~{r})-5-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate (371 Da, Ligand)
- Rna-directed rna polymerase (109 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Water (18 Da, Ligand)
- Templete (9 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Primer (6 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
- The nsp12-nsp7-nsp8 complex bound to the template-primer rna and triphosphate form of remdesivir(rtp) (Complex from SARS bat coronavirus)
- Pyrophosphate 2- (175 Da, Ligand)