Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the Naproxen-bound state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8jh5
Q-score: 0.44
To Be Published
- (2s)-2-(6-methoxynaphthalen-2-yl)propanoic acid (230 Da, Ligand)
- Nanobody (13 kDa, Protein from Escherichia coli)
- Binary complex of pin1 with nanobody (Complex from Arabidopsis thaliana)
- Auxin efflux carrier component 1 (67 kDa, Protein from Arabidopsis thaliana)
Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8ij3
Q-score: 0.506
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ Pubmed: 38012147 DOI: doi:10.1038/s41421-023-00610-7 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex without ligand (apo state) (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with niacin
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ija
Q-score: 0.574
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ Pubmed: 38012147 DOI: doi:10.1038/s41421-023-00610-7 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with niacin (Complex from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with acipimox
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8ijb
Q-score: 0.497
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with acipimox (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
Cryo-EM structure of human HCAR2-Gi complex with MK-6892
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8ijd
Q-score: 0.452
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ Pubmed: 38012147 DOI: doi:10.1038/s41421-023-00610-7 ]
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with mk-6892 (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the apo state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7y9t
Q-score: 0.528
Yang Z, Xia J, Hong J, Zhang C, Wei H, Ying W, Sun C, Sun L, Mao Y, Gao Y, Tan S, Friml J, Li D, Liu X, Sun L
Nature (2022) 609 pp. 611-615 [ Pubmed: 35917925 DOI: doi:10.1038/s41586-022-05143-9 ]
- Nanobody (13 kDa, Protein from Escherichia coli)
- Auxin efflux carrier component 1 (67 kDa, Protein from Arabidopsis thaliana)
- Atpin1 (Complex from Escherichia coli)
- Atpin1 in complex with a nanobody (Complex from Arabidopsis thaliana)
- Nanobody (Complex)
Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the NPA-bound state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7y9u
Q-score: 0.492
Yang Z, Xia J, Hong J, Zhang C, Wei H, Ying W, Sun C, Sun L, Mao Y, Gao Y, Tan S, Friml J, Li D, Liu X, Sun L
Nature (2022) 609 pp. 611-615 [ Pubmed: 35917925 DOI: doi:10.1038/s41586-022-05143-9 ]
- Nanobody (13 kDa, Protein from Escherichia coli)
- Atpin1 in complex with a nanobody and npa (Complex from Arabidopsis thaliana)
- Auxin efflux carrier component 1 (67 kDa, Protein from Arabidopsis thaliana)
- Atpin1 (Complex from Escherichia coli)
- 2-(naphthalen-1-ylcarbamoyl)benzoic acid (291 Da, Ligand)
- Nanobody (Complex)
Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the IAA-bound state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7y9v
Q-score: 0.499
Yang Z, Xia J, Hong J, Zhang C, Wei H, Ying W, Sun C, Sun L, Mao Y, Gao Y, Tan S, Friml J, Li D, Liu X, Sun L
Nature (2022) 609 pp. 611-615 [ Pubmed: 35917925 DOI: doi:10.1038/s41586-022-05143-9 ]
- Nanobody (13 kDa, Protein from Escherichia coli)
- Water (18 Da, Ligand)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
- Atpin1 in complex with a nanobody and npa (Complex from Arabidopsis thaliana)
- Auxin efflux carrier component 1 (67 kDa, Protein from Arabidopsis thaliana)
- Atpin1 (Complex from Escherichia coli)
- Nanobody (Complex)