Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hlp
Q-score: 0.435
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ Pubmed: 38555290 DOI: doi:10.1038/s41467-024-47116-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Hexadecane (226 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8hma
Q-score: 0.424
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ DOI: doi:10.1038/s41467-024-47116-8 Pubmed: 38555290 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Cav1.2alpha2delta1beta2b (Complex from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman (620 Da, Ligand)
- Beta-d-mannopyranose (180 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8hmb
Q-score: 0.472
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ DOI: doi:10.1038/s41467-024-47116-8 Pubmed: 38555290 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- (3r)-1-benzylpiperidin-3-yl methyl (2r,3r,4r,5r,6s)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate (506 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of human NaV1.6/beta1/beta2,apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gz1
Q-score: 0.391
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ Pubmed: 36823201 DOI: doi:10.1038/s41467-023-36766-9 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz2
Q-score: 0.422
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ Pubmed: 36823201 DOI: doi:10.1038/s41467-023-36766-9 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (1r,2s,3s,4r,5r,9s,11s,12s,14r)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name) (301 Da, Ligand)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xlq
Q-score: 0.482
Gao Y, Xu S, Cui X, Xu H, Qiu Y, Wei Y, Dong Y, Zhu B, Peng C, Liu S, Zhang XC, Sun J, Huang Z, Zhao Y
Nat Commun (2023) 14 pp. 516-516 [ Pubmed: 36720859 DOI: doi:10.1038/s41467-023-36260-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (65 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Human r-type voltage-gated calcium channel cav2.3-alpha2/delta1-beta1 complex (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent r-type calcium channel subunit alpha-1e (262 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (122 kDa, Protein from Homo sapiens)
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7xr4
Q-score: 0.532
Zhang Z, Chen H, Geng Z, Yu Z, Li H, Dong Y, Zhang H, Huang Z, Jiang J, Zhao Y
Nat Commun (2022) 13 pp. 3329-3329 [ Pubmed: 35680945 DOI: doi:10.1038/s41467-022-31031-x ]
- Transporter (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Excitatory amino acid transporter 2 (62 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7xr6
Q-score: 0.511
Zhang Z, Chen H, Geng Z, Yu Z, Li H, Dong Y, Zhang H, Huang Z, Jiang J, Zhao Y
Nat Commun (2022) 13 pp. 3329-3329 [ Pubmed: 35680945 DOI: doi:10.1038/s41467-022-31031-x ]
- Dodecyl beta-d-glucopyranoside (348 Da, Ligand)
- Transporter (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- (2s)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid (415 Da, Ligand)
- Excitatory amino acid transporter 2 (62 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
CryoEM structure of human low-voltage activated T-type calcium channel CaV3.3 (apo)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7wli
Q-score: 0.443
He L, Yu Z, Geng Z, Huang Z, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y
Nat Commun (2022) 13 pp. 2084-2084 [ DOI: doi:10.1038/s41467-022-29728-0 Pubmed: 35440630 ]
- Voltage-dependent t-type calcium channel subunit alpha-1i (245 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cav3.3 (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wlj
Q-score: 0.366
He L, Yu Z, Geng Z, Huang Z, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y
Nat Commun (2022) 13 pp. 2084-2084 [ Pubmed: 35440630 DOI: doi:10.1038/s41467-022-29728-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cav3.3 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1i (245 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (1s,2s)-2-(2-{[3-(1h-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate (495 Da, Ligand)