Block-based reconstruction (block C) of the outer capsid and membrane of the ranavirus Frog Virus 3

Alpha-Synuclein Type 1D Fibrils at pH 7.4 formed by a 19:1 mixture of full-length protein and residues 5-140 (coexisting with 1m in sample 60)

Alpha-Synuclein Type 6m Fibrils at pH 7.4 formed under strong agitation (coexisting with 6B and 2A in sample 44)

Full-length MICAL1 in the oxidized and autoinhibited state vitrified in the presence of NADPH

Photosystem II from Arabidopsis thaliana following high light and high temperature treatment

Alpha-Synuclein Type 1A Fibrils at pH 7.0 formed by a 19:1 mixture of full-length protein and residues 5-140.

Alpha-Synuclein Type 5A Fibrils. Helical reconstruction with ambiguous symmetry (here as C1)

Alpha-Synuclein Type 1A Fibrils at pH 7.4 (variant 1 of 2 in same sample)

Alpha-Synuclein Type 5A Fibrils. Helical reconstruction with ambiguous symmetry (here as 2-start C1)

Full-length MICAL1 in the oxidized and autoinhibited state

Block-based reconstruction (block B) of the outer capsid and membrane of the ranavirus Frog Virus 3

Alpha-Synuclein Type 2B(-NS) Fibrils at pH 7.0 formed by an N-terminal truncation comprising residues 5-140.

Alpha-Synuclein Type 3C Fibrils at pH 5.8 with 2-start helical symmetry

1-protofilament map of taxol stabilized human microtubule using CsMT workflow

2-protofilament heterotypic (seam) map of taxol stabilized human microtubule using CsMT workflow

2-protofilament homotypic map of of taxol stabilized human microtubule using CsMT workflow

1-protofilament map of KIF5A decorated microtubule using CsMT workflow

Azotobacter vinelandii FixABCX - as purified

yeast core m6A Methyltransferase Complex (ycMTC)

SARS-CoV2 KP.3 with fab JN.1-9 local refinement

Cryo-electron Tomogram of a whole Chlamydia trachomatis elementary body

Nitrogenase-like reductase CfbC/D

Cryo-electron Tomogram of a FIB milled Chlamydia trachomatis elementary body

Cryo-electron Tomogram of a FIB milled Chlamydia trachomatis elementary body

BA3.2.2 SARS-CoV-2 Spike

yeast core m6A Methyltransferase Complex (ycMTC) bound to mRNA

SARS-CoV2 KP.3 with fab JN.1-10 local refinement

Cryo-electron Tomogram of a whole Chlamydia trachomatis elementary body exposed to trifunctional sphingomyelin derivatives (TFSM)

Structure of AIIMS 44m bnAbs with AIIMS 330.v7 trimer

Cryo-EM structure of DOCK11

Filament structure of murine Reg3gamma

Structure of a glycosylated Vibrio alginolyticus lateral flagellar filament

Structure of mouse RyR1 mutant T4706M (EGTA-only dataset)

Cryo-EM structure of DOCK11 complexed with Cdc42(G15A)

Cryo-EM structure of DOCK11 complexed with Cdc42(G15A) and Cdc42(Q61L)-GTP in the membrane-bound state

Cryo-EM structure of DOCK11 complexed with Cdc42(G15A) and Cdc42(Q61L)-GTP

Pseudomonas aeruginosa 50S ribosome (L1 stalk in 'mid' conformation)

Structure of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

Raw consensus map of mouse RyR1 mutant T4706M (EGTA-only dataset)

Structure of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on S2S3 of mouse RyR1 mutant T4706M (EGTA-only dataset)

Constituent EM map: Focused refinement on TaF+TMD+CTD of mouse RyR1 mutant T4706M (EGTA-only dataset)

Constituent EM map: Focused refinement on JSol+CSol of mouse RyR1 mutant T4706M (EGTA-only dataset)

Constituent EM map: Focused refinement on NTD+SPRY+Calstabin-1 of mouse RyR1 mutant T4706M (EGTA-only dataset)

Constituent EM map: Focused refinement on BSol of mouse RyR1 mutant T4706M (EGTA-only dataset)

Constituent EM map: Focused refinement on Ry12 of mouse RyR1 mutant T4706M (EGTA-only dataset)

Constituent EM map: Focused refinement on Ry34 of mouse RyR1 mutant T4706M (EGTA-only dataset)

Constituent EM map: Focused refinement on NTD+SPRY+Calstabin-1 of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Raw consensus map of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on JSol+CSol of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on S2S3 of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on BSol of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on Ry12 of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on Ry34 of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on TaF+TMD+CTD of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; closed pore)

Constituent EM map: Focused refinement on NTD+SPRY+Calstabin of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

Raw consensus map of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

Constituent EM map: Focused refinement on BSol of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

Constituent EM map: Focused refinement on TaF+TMD+CTD of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

Constituent EM map: Focused refinement on JSol+CSol of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

Constituent EM map: Focused refinement on Ry34 of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

pointed end of actin filament with one Lmod2 molecule bound

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus S-nidradine

Constituent EM map: Focused refinement on S2S3 of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

pointed end of actin filament with two Lmod2 molecules bound

Constituent EM map: Focused refinement on Ry12 of mouse RyR1 mutant T4706M (Ca2+/CFF/ATP dataset; open pore)

Cryo-EM structure of L9-yd19 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP) Kenya2-3 strain

Cryo-EM structure of L9-yd19 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP) 3D7 strain

photosystem I with six LHCIfrom a green alga as lichen phycobiont

photosystem I core from a green alga as lichen phycobiont

photosystem I with eight LHCI from a green alga as lichen phycobiont

Cryo-EM structure of CRU4 cruciferin homohexamer, an 11S globulin from Brassica napus

5HT2AR-miniGq heterotrimer in complex with a novel agonist IHCH-8152

6LHCI of PSI

photosystem I with two LHCI from a green alga as lichen phycobiont

Lhca2-Lhca9

PSI with 8LHCI from Diplosphaera chodatii

Cryo-EM structure of bacteriophage A1002 overall capsid

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5

Vibrio cholerae competence pilus

K1R - hexagonally ordered nanofibril

Structural characterization of hibernating ribosomes in the Gram-negative pathogen Pseudomonas aeruginosa

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5

CRYO-EM FOCUSED REFINEMENT MAP OF TRYPANOSOMA BRUCEI BLOODSTREAM FORM 80S RIBOSOME : NATIVE VACANT

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5

CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI BLOODSTREAM FORM 80S RIBOSOME : NATIVE VACANT

Maps of the RNA filaments from the first layer of PcV genome

CRYO-EM CONSENSUS MAP OF TRYPANOSOMA BRUCEI BLOODSTREAM FORM 80S RIBOSOME : NATIVE VACANT

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5

GFAP intermediate filament

Mycobacterium tuberculosis gyrase holocomplex with 150 bp DNA and corramycin

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5

Cryo-EM structure of rice ammonium transporter AMT1;1 T452D

Cryo-EM structure of rice ammonium transporter AMT1;1

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 11.8 twist 2.8

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 4.4 twist 2.6

Pseudomonas aeruginosa 50S ribosome (L1 stalk in 'out' conformation and missing uL1 and tRNA)

Tail domain of full-length phi-like human dynein-1 bound to dynactin-p150glued and LIS1

CryoEM Structure of Gq-coupled MRGPRX1 in complex with de novo protein mM1_060 (E12)

Pseudomonas aeruginosa 50S ribosome (L1 stalk 'in' conformation)

Consensus map of full-length phi-like human dynein-1 bound to dynactin-p150glued and LIS1

Pseudomonas aeruginosa 50S ribosome (L1 stalk in 'out' conformation)

The ligand free HCoV-HKU1 spike structure obtained from data collected on 100 kV Tundra at 180kX magnification with Falcon C detector

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 18.4 twist 1.7

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 7.7 twist -0.9

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 11.5 twist -3.9

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 12.0 twist 7.2

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 11.4 twist -1.6

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 6.9 twist 2.5

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 11.8 twist 2.2

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 11.8 twist 2.5

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 11.9 twist 5.9

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 8.5 twist 5.6

Tubulin cofactors D and E bound to beta tubulin

Tubulin cofactors D,E,G bound to beta tubulin

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 15.4 twist 4.6

Human Mfsd2b bound to S1P in outward-facing conformation, digitonin extraction

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 16.9 twist 1.9

Hexamer-hexamer interface from purified HIV-1 cores bound to lenacapavir tilt 15.5 twist -0.9

Human Mfsd2b bound to S1P in outward-facing conformation

cryo-EM structure of human Tryptophan 2,3-dioxygenase (TDO2)

Split Ring DNA Origami Structure

phospho-TDO2 tetramer in complex with bTrCP2-CUL1(NTD) dimer

cryo-EM structure of human Tryptophan 2,3-dioxygenase (TDO2)

Complex of phospho-TDO2 with E3 ligase CUL1-bTrCP2

cryo-EM map of TDO2 with Trp

cryo-EM structure of human Tryptophan 2,3-dioxygenase (TDO2)

Cryo-EM reconstruction of CDK11-cyclin L-SAP30BP in the presence of cryo-tide

Cryo-EM reconstruction of CDK11-cyclin L-SAP30BP without cryo-tide

Complex of phospho-TDO2 with E3 ligase CUL1-bTrCP2

TBC D,E,Arl2 bound to beta tubulin, TBCD,Arl2,beta tubulin

Dimer of tubulin folding cofactors D and E bound to beta tubulin in the back to back orientation

Dimer of tubulin cofactors D,E, and Arl2 bound to beta tubulin in a back to back orientation

Dimer of tubulin folding cofactors D and E bound to beta tubulin in a side to side orientation

Cryo-EM structure of human IL-10RA in complex with VHH E07

Cryo-EM structure of human IL-10RA and IL-10RB in complex with tandem VHHs E07-A05

TBC D,E,Arl2 bound to beta tubulin, TBC E focus

Undecorated pointed end of actin filament in presence of Lmod2

Barbed end of actin filament in presence of Lmod2

Subtomogram Average of the Ribosome-Multipass Translocon Complex

Subtomogram Average of the Ribosome-Multipass Translocon-EMC Complex

LPT translocon complex from Flavobacter johnsoniae built in composite volume

LPT translocon complex from Bacteroides thetaiotaomicron - focus volume, membrane and extracellular region

Structure of Fab 04-1D02 in complex with hemagglutinin from influenza A (A/Hawaii/70/2019) H1N1

LPT translocon complex from Bacteroides thetaiotaomicron - consensus volume

LPT translocon complex from Bacteroides thetaiotaomicron - focus volume, periplasmic region

LPT translocon complex from Bacteroides thetaiotaomicron built in composite volume

Structure of Fab 53-1A09 in complex with hemagglutinin from influenza A (A/Solomon Island/3/2006) H1N1

Alpha-Synuclein Type 1A Fibrils at pH 7.0 (co-existing with 1/7, 2A and 5A fibrils in Sample 45)

Polyclonal immune complex comprising SARS-CoV-2 spike (BA.2.87.1) and a class 1 RBD-Down-targeting antibody - Obtained by negative stain EM

Alpha-Synuclein Type 1A Fibrils at pH 7.4 (layer-traversing variant) formed by an N-terminal truncation comprising residues 5-140

Alpha-Synuclein Type 2E(-NS) Fibrils at pH 6.3

Alpha-Synuclein Type 2A Fibrils at pH 7.0 (co-existing with 2B, 5A and 5B fibrils in Sample 23)

Polyclonal immune complex comprising SARS-CoV-2 spike (Wuhan) and a class 1 RBD-Down-targeting antibody - Obtained by negative stain EM

Alpha-Synuclein Type 5A Fibrils. Helical reconstruction with ambiguous symmetry (here as C2)

Block-based reconstruction (block D) of the outer capsid and membrane of the ranavirus Frog Virus 3

Alpha-Synuclein Type 5A Fibrils at pH 7.0 (co-existing with 2A, 2B and 5B fibrils in Sample 23)

Alpha-Synuclein Type 1/7 Fibrils at pH 7.0 (co-existing with 1A, 2A and 5A fibrils in Sample 45)

Alpha-Synuclein Type 5B Fibrils at pH 7.0 (co-existing with 2A, 2B and 5A fibrils in Sample 23)

Alpha-Synuclein Type 1A Fibrils at pH 7.4 (variant 2 of 2 in same sample)

Alpha-Synuclein Type 2B Fibrils at pH 7.0 (co-existing with 2A, 5A and 5B fibrils in Sample 23)

Alpha-Synuclein Type 2A Fibrils at pH 7.0 (co-existing with 1A, 1/7 and 5A fibrils in Sample 45)

Alpha-Synuclein Type 2A(-NS) Fibrils at pH 7.0 formed by a 1:1 mixture of full-length protein and residues 5-140.

Polyclonal immune complex comprising SARS-CoV-2 spike (BA.2.87.1) and a class 1 RBD-Up-targeting antibody - Obtained by negative stain EM

Alpha-Synuclein Type 5A Fibrils at pH 7.0 with 2-start helical symmetry (co-existing with 1A, 1/7 and 2A fibrils in Sample 45)

Alpha-Synuclein Type 8/9 Fibrils at pH 7.0 formed by an N-terminal truncation comprising residues 5-140.

Alpha-Synuclein Type 1A Fibrils at pH 7.4 formed by a 1:1 mixture of full-length protein and residues 5-140 (2.1 Angstrom FSC resolution with choppy density)

Alpha-Synuclein Type 1m Fibrils at pH 7.4 formed by a 19:1 mixture of full-length protein and residues 5-140 (co-existing with 1D in sample 60)

Polyclonal immune complex comprising SARS-CoV-2 spike (Wuhan) and a class 1 NTD-targeting antibody - Obtained by negative stain EM

Alpha-Synuclein Type 6B Fibrils at pH 7.4 formed under strong agitation (coexisting with 6m and 2A in sample 44)

Alpha-Synuclein Type 1/7 Fibrils at pH 7.0 formed by a 1:1 mixture of full-length protein and residues 5-140.

Polyclonal immune complex comprising SARS-CoV-2 spike (Wuhan) and a class 2 NTD-targeting antibody - Obtained by negative stain EM

Polyclonal immune complex comprising SARS-CoV-2 spike (Wuhan) and a class 1 RBD-Up-targeting antibody - Obtained by negative stain EM

Outer capsid and inner membrane of the ranavirus Frog Virus 3

Consensus map for full icosahedral reconstruction of the ranavirus Frog virus 3

Polyclonal immune complex comprising SARS-CoV-2 spike (BA.2.87.1) and a class 3 RBD-Up-targeting antibody - Obtained by negative stain EM

Polyclonal immune complex comprising SARS-CoV-2 spike (BA.2.87.1) and a class 2 RBD-Up-targeting antibody - Obtained by negative stain EM

Structure of the SARS-CoV-2 BA.2.87.1 spike protein ectodomain

Polyclonal immune complex comprising SARS-CoV-2 spike (Wuhan) and a class 2 RBD-Up-targeting antibody - Obtained by negative stain EM

Block-based reconstruction (block A) of the outer capsid and membrane of the ranavirus Frog Virus 3