Family A37
Summary for family A37
| Family type peptidase | A37.001 - sso1175 g.p. (Sulfolobus solfataricus) (Sulfolobus solfataricus), MEROPS Accession MER0812862 (peptidase unit: 26-601) |
| Content of family | Peptidase family A37 contains pepstatin-insensitive aspartic endopeptidases. |
| History |
Identifier created: MEROPS 11.0 (6 January 2017)
A thermophilic and acidophilic endopeptidase was identified in the archaean Sulfolobus solfataricus and named SsMTP-1; the protein is the product of the sso1175 gene (Cannio et al., 2010).
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| Catalytic type | Aspartic |
| Active site | The nature of the active site has not been determined. Because characteristics and distribution are similar to that of thermopsin, the SSO1175 peptidase is assumed to be an aspartic endopeptidase (Gogliettino et al., 2014). The sequence lacks cysteine residues, so the enzyme cannot be a cysteine peptidase.
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| Activities and specificities | The only known activity is on the oxidized insulin B chain, which is not a physiological substrate. The peptidase is active at 70 degrees C and at pH 2.0 (Gogliettino et al., 2014).
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| Inhibitors | The SsMTP-1 peptidase is not inhibited by PMSF, EDTA or pepstatin (Gogliettino et al., 2014).
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| Molecular structure | The SSO1175 protein is believed to be multi-domain, with a peptidase domain followed by a PKD domain and a Y_Y_Y domain. PKD domains are involved in a variety of protein-protein interactions amongst extracellualr proteins. (Cannio et al., 2010). No tertiary structures have been solved.
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| Clan | unassigned |
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Distribution of family
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Bacteria |
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Archaea |
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Protozoa |
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Fungi |
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Plants |
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Animals |
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Viruses |
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