Family C107
Summary for family C107
| Family type peptidase | C107.001 - alphamesonivirus 3C-like peptidase (Cavally virus), MEROPS Accession MER0592262 (peptidase unit: 1387-1700) |
| Content of family | Family C107 contains polyprotein processing cysteine endopeptidases. |
| History |
Identifier created: MEROPS 10.0 (14 Mar 2016)
Family C107 includes the alphamesonivirus 3C-like peptidase. Mesoviruses, such as Cavally virus, are insect RNA virus related to, but divergent from, nidoviruses. The Merovirus RNA encodes two polyproteins, known as pp1a and pp1ab, from which structural and non-structural proteins are generated by proteolytic cleavage (Blanck et al., 2014). |
| Catalytic type | Cysteine |
| Active site residues | H1434 C1539 |
| Active site | The active site dyad has been identified by site directed mutagenesis to be His, Cys (Blanck et al., 2014). |
| Activities and specificities | The 3C-like peptidases has a preference for Asn in P2 and cleaves the polyprotein at two sites (Blanck et al., 2014). |
| Molecular structure | No tertiary structures have been solved. From the order of the active site residues, family C107 is assumed to be a member of subclan PA(C) and the peptidase to have a chymotrypsin-like fold. |
| Clan | PA |
| Subclan | PA(C) |
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Distribution of family
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Bacteria |
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Archaea |
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Protozoa |
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Fungi |
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Plants |
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Animals |
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Viruses |
details |
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