Family C110
Summary for family C110
Family type peptidase | C110.001 - kyphoscoliosis peptidase (Mus musculus), MEROPS Accession MER0472834 (peptidase unit: 169-283) |
Content of family | Family C110 contains cysteine endopeptidases. |
History |
Identifier created: MEROPS 10.0 (14 Mar 2016) Family C110 includes the mammalian kyphoscoliosis peptidase. Kyphoscoliosis is curvature of the spine and a mutant (in the KY gene) associated with the condition was first identified in mouse (Blanco et al., 2001). The KY protein was shown to be a peptidase that degrades filamin C (Beatham et al., 2004). Other mutations causes a truncated KY protein and affects muscle development but does not cause scoliosis (Hedberg-Oldfors et al., 2016), congenital myopathy (Straussberg et al., 2016) and progressive hereditary spastic paraplegia (Yogev et al., 2017). |
Catalytic type | Cysteine |
Active site residues | C225 H267 D282 |
Active site | A Cys, His, Asp catalytic triad has been proposed Beatham et al., 2004). |
Molecular structure | No tertiary structure has been solved for any member of the family. The KY protein has a transglutaminase-like domain. On the basis of the order of the residues in the proposed catalytic triad, family C110 is included in clan CA. |
Clan | CA |